introduction: listeria monocytogenes is a gram positive bacteria, frequently found in the environment and is responsible for food-borne disease such as perinatal infections, septicameia and meningeonceohalitis in human and animals. material and methods: for this reason, distribution of the ctpa determinate among l. monocytogenes isolated from clinical environment, diry and poultry samples were ...

Abstract Inherited eye diseases have been the subject of genetic research for many years. This paper focuses on optimisation DNA test based polymerase chain reaction (PCR) detection Collie Eye Anomaly (CEA) in dogs. A small family four longhaired Collies (parents and their daughters) with a confirmed positive clinical ophthalmologic examination CEA served as source affected animals. Both PCR co...

Breast cancer (BC) is not a typical manifestation of Lynch syndrome. The existence and extent excessive breast risk in carriers pathogenic mutations the syndrome-associated genes (MLH1, MSH2, MSH6, PMS2) remains an open question. In addition, it known that some neoplasms patients with this syndrome are causally linked to hereditary mutation, arise completely independently defect gene DNA mismat...

Abstract Background Genetic predisposition is one of the risk factors for development multiple primary cancers (MPCs), frequency which increases and ranges from 2 to 17%. This study describes a combination rare mutations, rs746551843 in NOTCH2 gene rs144933006 SDK2 gene, woman with breast cancer leiomyosarcoma without clearly burdened family history. Case presentation A 55-year-old Caucasian re...

background: available drugs are not able to eradicate intracellular viral dna in patients with hepatitis b virus (hbv) infections. hbsag vaccine could induce immunity and subsequently eradicate hepatitis b virus in proportions of these patients. our aim was to evaluate the efficacy of hbsag as a mode of therapy in inactive carriers. materials and methods: forty two consecutive patients of inact...

background and objectives: neisseria meningitidis is transmitted from person-to-person. thus, close contact with a healthy carrier can facilitate the spread of the bacteria and lead to life-threatening meningococcal disease. the aim of this study was to identify oropharyngeal carriers of n. meningitidis in volunteers preparing for military service before vaccination. materials and methods: in a...

background: it is estimated that about 370 million people are chronic carriers of hbv worldwide. apparently 3% of iranian populations are chronic carriers of this virus. we aimed to evaluate the viral dna in biological fluids of chronic hepatitis patients compared to a control group. methods: the current case-control study was designed to evaluate the viral dna in biological fluids of 70 chroni...

The ADP/ATP carrier of yeast (309 amino acids) is an abundant transmembrane protein of the mitochondrial inner membrane whose import involves well-defined steps (Pfanner, N., and Neupert, W. (1987) J. Biol. Chem. 262, 7528-7536). Analysis of the in vitro import of gene fusion products containing ADP/ATP carrier (AAC) sequences at the amino terminus and mouse dihydrofolate reductase (DHFR) at th...

background: breast cancer is the most common malignancy among women. it is estimated that 1 in 10 women worldwide is affected by breast cancer during their lifetime. in 5 to 10% of breast cancer patients, the disease results from a hereditary predisposition, which can be attributable to mutations in either of two tumor suppressor genes, brca1 and brca2 to a large extent. brca2 6174delt mutation...

tropical theileriosis is a tick-transmitted disease which caused by obligative intracellular protozoan theileria annulata. diagnosis is usually based on identification of parasite in giemsa stained smears of peripheral blood, spleen or lymph nodes. today, the molecular methods with high sensitivity and specificity are used for diagnosis of infected and carrier animals, epidemiological and phylo...