Abstract Background The daily peak in dopaminergic neuronal activity at the area of biological clock (hypothalamic suprachiasmatic nuclei [SCN]) is diminished obese/insulin resistant vs lean/insulin sensitive animals. impact targeted lesioning dopamine (DA) neurons specifically surrounding (and that communicate with) SCN (but not within itself) upon glucose metabolism, adipose and liver lipid g...

Human and animal diabetes mellitus were controlled by a dietary treatment supplemented with either a sulfonylurea drug or insulin injection. Insulin injections were inconvenient and the hypoglycemia induced by insulin-overdose could be fatal. Sulfonylurea drugs were administered orally, however, do not typically provide satisfactory control of blood glucose as a starting treatment in 25% 30% pa...

introduction: hepatitis c virus (hcv) is the major cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. because of increasing number of infected patients throughout the world, various studies are concentrated on development of high quality diagnostic tests and genotyping in various regions of the world. methods: in this study, we used rt-pcr to isolate and a...

Background & Aims: Type 1 diabetes, or insulin-dependent diabetes, is an autoimmune disease in which pancreatic beta cells are destroyed by the immune system. Hitherto, no definite treatment has been found for this condition. Mesenchymal stem cells (MSCs) are multipotent, self-renewing cells that have the ability to differentiate into mesodermal tissues. This ability has attracted the attention...

background: it has been demonstrated that insulin signaling pathway related genes have important roles in polycystic ovary syndrome (pcos) risk. the goal of present investigation was to assess the potential association between insr/nsii (rs2059806) and insr/pmli (rs1799817) snps and pcos. methods: 50 women with pcos and 47 normal controls entered the study. nsii and pmli snps in the insr gene w...

Background: One of the most important metabolic factors affecting the reproductive activity is insulin-like growth factor-I (IGFI) concentration changes after calving. Recently, Maj et al. (2008) discovered a significant association between the IGF-I genotypes based on the 5'-untranslatedregion (5'-UTR) of IGF-I gene and the IGF-I blood level. The objective of this study is to investi...

The mechanism of insulin gene transcription control in response to glucose concentration is poorly defined. The islet-restricted transcription factors PDX1 and ISL1 interact with BETA2, activating insulin gene expression. However, their contribution and hierarchical organization in insulin expression control based on glucose concentration remain unknown. We investigated PDX1 and ISL1 regulation...

the genetic polymorphism of some genes related to meat production in three egyptian sheep breeds (barki, rahmani and osseimi) was studied. the candidate genes were: calpastatin, myostatin, diacylglycerol-acyltransferase1, insulin-like growth factor binding protein-3 and booroola fecundity gene. the technique applied was the restriction fragment length polymorphism for the polymerase chain react...

This investigation aimed to study polymorphism of growth hormone (GH), growth hormone receptor (GHR), and insulin like growth factor 1 (IGF-1) genes and their associations with growth and carcass traits in Mazandaran native chicken. 200 male chicks were reared and slaughtered at 12 weeks of age. Traits including live weight at 4, 8 and 12 weeks of age, body weight and weights of heart, liver, g...