Background: Type 2 diabetes mellitus that characterized by insulin resistance and it is a risk of many diseases the impact genetic factors on well documented. Vitamin D receptor (VDR) gene polymorphisms have been linked to T2DM. In this study, we analyzed relation between TaqI ApaI VDR T2DM subjects using PCR-RFLP method in Kurdish patients.

Objective(s):The aim of the study was to investigate the relationship between insulin resistance (IR) and leptin (LEP) gene polymorphisms in peritoneal dialysis (PD) patients. Materials and Methods: From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR-IR, and low HOMR-IR). Two PCR products of LEP were sequenced and aligne...

This study investigated the effects and mechanism of actions neochlorogenic acid (3-caffeoylquinic acid; 3-CQA) on glucose lipid metabolism in rats fed a high fat-high fructose diet (HFFD). Male were HFFD (40 % lard 20 fructose) for 16 weeks. At 10th week, split into 3 groups: receiving distilled water (HFFD control group), 3-CQA 50 mg/kg metformin 200 once daily further 6 end treatment, fastin...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

the present study was conducted to test the effect of origanum majoranum extract (ome) of leaves on alterations induced in a model of type 2 diabetic rats. adult male wistar rats were fed high fat diet for 3 weeks and injected a single dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetic rats. diabetic rats were given aqueous extract of ome in a dose of 20 mg/kg orally ...

The insulin/insulin-like growth factor signaling (IIS) pathway is one of the key elements in an organism’s response to unfavourable conditions. deep homology this and its evolutionary conservative role controlling carbohydrate lipid metabolism make it possible use Drosophila melanogaster for studying functioning. To identify properties interaction two IIS components under heat stress D. (the fo...