Beta-thalassemia (β-thal) is a congenital hemoglobinopathy explained by a decreased level (β+) or absence (βο) of β-globin gene expression. Microcytic hypochromic anemia and various clinical symptoms comprising severe anemia to clinically nonsymptomatic features. Treatment with an ordered blood transfusion and iron chelator agents can decrease transfusion iron overload that causes normal matura...

Abstract Epigenetic genome engineering expands our capabilities from modifying the DNA sequence to controlling its regulation. It provides ability change epigenetic marks at defined genomic loci control gene expression without need for an intervention in genetic code. This short review touches on current approaches of editing with a focus long-term silencing.