BACKGROUND There is strong and consistent evidence that a genetic component contributes to the etiology of chronic lymphocytic leukemia (CLL). A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population. METHODS We evaluated the association of these variants, or variants in linkage disequilibrium with these varian...

Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) in 12 caspase and related genes in 3 population-based case-control studies (194...

Most of economic and financial time series have a nonstationary behavior. There are different types of nonstationary processes, such as those with stochastic trend and those with deterministic trend. In practice, it can be quite difficult to distinguish between the two processes. In this paper, we compare random walk and determinist trend processes using sample autocorrelation, sample partial a...

Genetic trends for weaning weight were evaluated in 15 purebred herds in the United States participating in the Angus Herd Improvement. Records production testing program. Regression techniques were used for separate estimates of sire and dam contributions that were summed to estimate total herd trend. Sire contributions, calculated as the pooled within sire regression of weaning weight ratio o...

Type B genetic correlations were used to examine the relation among geographic differences between sites and their siteto-site genetic (Type B) correlations. Examination of six local breeding zones in Oregon indicated that breeding zones were, for the most part, not too large because few environmental variables were correlated with Type B genetic correlations. The data also were used to examine...

INTRODUCTION This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort. METHODS The magnitude of association for each genotype was assessed in 1,046 RA subjects from the Yorkshire Early RA cohort and in 5,968 healthy UK controls. Additi...

The role of genetic polymorphisms in pediatric brain tumor (PBT) etiology is poorly understood. We hypothesized that single nucleotide polymorphisms (SNPs) identified in genome-wide association studies (GWAS) on adult glioma would also be associated with PBT risk. The study is based on the Cefalo study, a population-based multicenter case-control study. Saliva DNA from 245 cases and 489 control...

PURPOSE To evaluate the effects of tafluprost treatment for 3 years on intraocular pressure (IOP) and visual field performance. METHODS The IOP of 55 patients with normal-tension glaucoma was monitored every 1-3 months for 3 years. The Humphrey visual field test was performed every 6 months after treatment and results compared with before-treatment results. Visual field performance was also e...

Predictions of uprising or falling trends are helpful in different scenarios in which users have to deal with huge amount of information in a timely manner,such as during financial analysis. This temporal aspect in various cases of data analysis requires novel data mining techniques. Assuming that a given set of data, e.g. web news, contains information about a potential trend, e.g. financial c...