Metabolic syndrome has a high prevalence (about 22.4% in adult individuals) in developed countries. Inflammation due to obesity and fat accumulation is the most important factor in the progression of metabolic syndrome. In cells which have a receptor for insulin hormone, inflammatory mediators target the insulin signaling pathway and cause insulin resistance. Peroxisome proliferator-activated r...

Soy intake has been associated with a lower risk of prostate cancer. Soybeans contain isoflavones, genistein, daidzein and glycitein, which have shown anti-cancer effects in cell culture animal studies. Recently clinical trials soy isoflavones humans also promising results. anti-oxidant anti-inflammatory properties may be important for their anticancer effects. In addition, recent studies signi...

•Methyl-piperidino-pyrazole downregulated phosphorylated estrogen receptor-? (S118).•Genistein further decreased the levels of receptor-?.•Genistein reduced proliferation JEG-3 human choriocarcinoma cells.•Genistein Ki-67 in cells. Background & aimsChoriocarcinoma is a malignant trophoblastic tumor. The phosphorylation at serine 118 (p-ER-s118) decreases cancer cell proliferation. However, effe...

soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. however, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 mapk) as the main therapeutic targets were...

SCOPE Genistein from foods or supplements is metabolized by the gut microbiota and the human body, thereby releasing many different metabolites into systemic circulation. The order of their appearance in plasma and the possible influence of food format are still unknown. This study compared the nutrikinetic profiles of genistein metabolites. METHODS AND RESULTS In a randomized cross-over tria...

Objective(s): Genistein, as a phytoestrogen found in legumes, has several biological activities in general and anti-diabetic activity particularly. In this study, we investigated the effect of genistein on proteins involved in β-cell proliferation, survival and apoptosis to further reveal its anti-diabetic potential in the ovariectomized diabetic rat. Materials and Methods: We used three-month-...

Utilization of genistein as a natural inhibitor was studied alone and in combination with conventional treatments on melanosis and microbial quality of fresh L. vannamei during 10 days ice storage. Treatments were as followed: A (dipping samples in distilled water), B (dipping in 1.25 % sodium metabisulphite solution), C (dipping in 0.01 % genistein + 2% glycerol solution), D (dipping in 0.1 % ...

Objective: The purpose of this study was to investigate the effects of endurance training accompany with taking genistein on Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and C-reactive protein (CRP) levels in diabetic rats. Materials and Methods: Sixty-four rats were divided into eight groups (1; healthy &sacrificed  at the first week, 2; healthy...

background: the predominant phytoestrogen in soy and derived products is the isoflavone genistein. genistein has antioxidant properties. morphine is a main psychoactive chemical in opium that can increase the generation of free radicals and therefore it could adversely affects the spermatogenesis. objective: the main goal was to investigate whether the genistein could protect morphine adverse e...