Genome-wide association studies directly assay 10 single nucleotide polymorphisms (SNPs) across a study cohort. Probabilistic estimation of additional sites by genotype imputation can increase this set of variants by 10to 40-fold. Even with modest sample sizes (10−10), these resulting “imputed” datasets, containing 10 − 10 double-precision values, are incompatible with simultaneous lossless sto...

Abstract Integrating gene expression across tissues and cell types is crucial for understanding the coordinated biological mechanisms that drive disease characterize homoeostasis. However, traditional multi-tissue integration methods either cannot handle uncollected or rely on genotype information, which often unavailable subject to privacy concerns. Here we present HYFA (hypergraph factorizati...

Abstract A growing literature points to children’s influence on parents’ behavior, including parental investments in children. Further, previous research has shown differential response by socioeconomic status birth weight, cognitive ability, and school outcomes—all early life predictors of later success. This study considers an even earlier, more exogenous predictor investments: offspring geno...

Genotyping, imputation and quality control Study samples are described in Table 1. Study specific parameters and pre-imputation filters are specified in Table S1. Each study applied similar criteria for data calling. Prior to imputation, the criteria applied for exclusion of SNPs were: (i) minor allele frequency (MAF) <0.01, (ii) Hardy-Weinberg equilibrium P <10-4 or 10-6 and (iii) call-rate <0...