The thyroid hormone is essential for the proper development of the central nervous system (CNS). Hormone deficiency during CNS development causes neurological abnormalities in the brain. The hippocampus is one of the brain regions vulnerable to hormone deficiency, and the volume of dentate gyrus (DG) and cornu ammonis (CA) are reduced by transient hypothyroidism during CNS development. However,...

introduction: many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. methods: pregnant rats were divided into the fetal hypothyroidism (fh) and the control (c) groups. ...

  Background and Objective: Hypertensive disorders complicating pregnancy are common and from one of the deadly triad, along with hemorrhage and infection that contribute greatly to prenatal and maternal morbidity and mortality in the developing countries. This study was designed to investigate the relationship between maternal hypothyroidism and pre-eclampsia. Materials and Methods: In a pro...

We report a twin pregnancy complicated by fetal goitrous hypothyroidism secondary to dyshormonogenesis caused by thyroglobulin deficiency. Antenatal treatment with intra-amniotic thyroxine was considered but not performed, given the late gestational age at diagnosis and the multiple nature of the pregnancy. Both twins developed airway obstruction at delivery, requiring intubation and ventilatio...

Purpose: The aim of this study was to evaluate the relationship between thyroid hormone levels and clinical outcomes in preterm, small for gestational age (SGA) infants.
 Materials Methods: premature newborns (gestational ≤30 weeks) were divided into two groups as SGA non-SGA. Thyroid stimulating (TSH) free thyroxine (fT4) levels, frequency congenital hypothyroidism (CH), demographic chara...

background: the aim of this study was to investigate the relationship between congenital hypothyroidism and several variables using two different adjustment methods. methods: this matched case-control study was conducted in hamadan province, the west of iran, in 2012 enrolling neonates born between 2005 and 2011 and covered by screening program for congenital hypothyroidism. the neonates with t...

Background Children born to high-risk pregnancies are more likely experience adverse health outcomes later in life. As estimated, 15% of all at risk various life-threatening conditions leading maternal and foetal outcomes. Millennium Development Goal resulted the global reduction death from 390,000 275000 1990–2015). Similarly, keep this momentum, current United Nations Sustainable (SDG: 3.1) a...

Objective(s): Thyroid hormones play an essential role in fetal growth and maternal hypo-thyroidism which leads to cardiovascular deficiency in their offspring.  Considering this, we intended to investigate the impact of gestational hypothyroidism on offspring vascular contractibility and possible underlying mechanisms. Materials and Methods: Hypothyroidism was induced in female rats by administ...

Because thyroid disease is the second most common endocrine disease affecting women of reproductive age, obstetricians often care for patients who have been previously diagnosed with alterations in thyroid gland function. In addition, both hyperthyroidism and hypothyroidism may initially manifest during pregnancy. Obstetric conditions, such as gestational trophoblastic disease or hyperemesis gr...

Aim . To perform a systematic review of common risk factors and prognostic markers gestational diabetes mellitus (GDM) hypothyroidism (HT), as well maternal perinatal complications in these diseases. For achieving this task, we screened analysed the relevant data from publications PubMed database over past 6 years. Key Points A factor for both diseases is obesity, which characterized by pregest...