Gingivitis is one of the most frequent oral health disorders; P. gingivalis a keystone bacteria in disruption gum barrier and development inflammation. A next generation microbiome friendly, care ingredients dedicated to beauty are gaining interest. In this study, effects Saffron flower extract were investigated on gingipain activity, adhesion growth gingivalis, gingival keratinocytes junction ...

BACKGROUND/AIMS Clinical studies indicate that primary proinflammatory cytokines, such as interleukin-1beta (IL-1beta) are elevated in the gingival crevice around teeth with periodontitis but the secondary cytokines and chemokines, IL-6 and IL-8, are not. The human gingival epithelial cells (HGECs) lining the gingival sulcus respond to perturbation by microbes of dental plaque by releasing a wi...

Abstract Background Oral health status is directly associated with microbes present within it. The abundance of at the OSCC site more than its control site, representing possible role in progression development. Dysbiosis oral microbiota could be a crucial etiological risk factor elevation OSCC. This study aimed to analyze and assess: a) positive regulator cancer their b) pathways involved micr...

BACKGROUND Porphyromonas gingivalis produces outer membrane-attached proteins that include the virulence-associated cysteine proteinases RgpA and RgpB (Arg-gingipains) and Kgp (Lys-gingipain). The gingipains provide P. gingivalis with a general proteolytic tool for degradation of proteinaceous nutrients for growth. They are also essential for the processing and maturation of the major fimbriae ...