Small interfering RNAs (siRNAs) are small non-coding RNAs, comprising 21-23 nucleotides that regulate gene expression by transcriptionally repressing their complementary mRNAs. In particular, Krüppel-like factor 8 (KLF8) has been postulated to function as a tumor activator in various cancer cells, but not in glioblastoma. In the present study, we investigated the anti-tumorigenic effect of KLF8...

The accurate identification and thorough characterization of tumorigenic cells in glioblastomas are essential to enhance our understanding of their malignant behavior and for the design of strategies that target this important cell population. We report here that, in rat brain, the scaffolding protein IQGAP1 is a marker of brain nestin+ amplifying neural progenitor cells. In a rat model of glio...

Glioblastoma is the most aggressive, invasive and malignant type of glioma : a tumor which arises from the glial cells in the brain (Wrensch et al., 2002). Glioblastoma represents 54% of all the gliomas and 18% of all brain tumors (CBTRUS, 2011). It is the frequently occurring brain tumor in humans. Patients with glioblastoma usually survive 12-15 months or less after diagnosis. (Krex et al., 2...

Glioblastoma remains a devastating disease for which novel therapies are urgently needed. Here, we report that the Aurora-A kinase inhibitor alisertib exhibits potent efficacy against glioblastoma neurosphere tumor stem-like cells in vitro and in vivo. Many glioblastoma neurosphere cells treated with alisertib for short periods undergo apoptosis, although some regain proliferative activity upon...

Abstract Objective The purpose of this clinical trial was to examine the effect omega-3 fatty acids (W-3 FAs), nanocurcumin and their combination on serum levels gene expression VCAM in patients with episodic migraine. Results In study, 80 were randomly divided 4 groups receive for 2 months. Both showed remarkable decreases after single W-3 combined interventions. However, a borderline signific...

PURPOSE Little is known about the optimal clinical use of ABT-888 (veliparib) for treatment of glioblastoma. ABT-888 is a PARP inhibitor undergoing extensive clinical evaluation in glioblastoma, because it may synergize with the standard-of-care temozolomide (TMZ). We have elucidated important factors controlling ABT-888 efficacy in glioblastoma. EXPERIMENTAL DESIGN We used genetically engine...