Slow potentials evoked by odor stimulation were recorded from individual glomeruli in the olfactory bulb. Systematic analysis of responses to nine different, arbitrarily selected stimuli strongly suggests a certain amount of discrimination. This fact seems to reflect in the first synapse of the olfactory tract the type of discrimination that was recently demonstrated within olfactory neuroepith...

Since the early descriptions of Alport syndrome, when the glomerular basement membrane (GBM) was found split into multiple laminar strands, investigators have wondered about the contribution of various cell types in the differential synthesis of these strands1; podocytes and endothelia flanking the GBM were always potential candidates. To address this issue, investigators began to examine vario...

Purified human globin injected into rats forms aggregates which are identifiable by their characteristic appearance in thin sections in the electron microscope and by their positive autoradiographs when the globin is tritiated before injection. Globin is taken up by endothelial cells of glomerular capillaries and is transported across the cell within the limits of a surrounding membrane. Globin...

There are approximately one million glomeruli in each human kidney. Each glomerulus is composed of a tuft of capillary loops supported by the mesangium and enclosed in a pouchlike extension of the renal tubule of the nephron known as Bowman’s capsule. The glomerulus consists of four resident cell types, the mesangial cell, the glomerular endothelial cell, the visceral epithelial cell (podocyte)...

The glomerulus of the mammalian kidney is an intricate structure that contains an unusual filtration barrier that retains higher molecular weight proteins and blood cells in the circulation. Recent studies have changed our conception of the glomerulus from a relatively static structure to a dynamic one, whose integrity depends on signaling between the three major cell lineages: podocytes, endot...

In mammals, the kidneys originate in an embryo from mesoderm through three excretory organs, namely: Pronephros, Mesonephros, and Metanephros. After formation of Metanephros is completed, begin to form nephrogenesis mesenchymal cells located at tip ureteric bud, that contribute glomerulus Renal tubules. The stages albino mice age 14 19 days gestation were studied. It was obtained after sacrific...