نتایج جستجو برای: glucoronoxylomannan (gxm)

تعداد نتایج: 104  

Journal: :iranian journal of public health 0
ar salehie-nodeh;n ashkanizadeh;mr nikooie-mogaddam;a mirshafieii

glucoronoxylomannan (gxm) is the most important compound of polysaccharide capsule in cryptococcus neoformans that causes infection in its recognition as a foreign agent by immune system. because of its similarity with some naural compounds such as heparin and hyaloronic acid, this study was undertaken to determine the effect of polysaccharide compounds on blood coagulative process and renal pe...

2013
Erin E. McClelland Letizia M. Hobbs Johanna Rivera Arturo Casadevall Wayne K. Potts Jennifer M. Smith Jeramia J. Ory

Cryptococcus neoformans (Cn) is a pathogenic yeast and the cause of cryptococcal meningitis. Prevalence of disease between males and females is skewed, with males having an increased incidence of disease. Based on the reported gender susceptibility differences to Cn in the literature, we used clinical isolates from Botswanan HIV-infected patients to test the hypothesis that different gender env...

Journal: :Infection and immunity 2002
Pauline M Ellerbroek Andy I M Hoepelman Floor Wolbers Jaap Jan Zwaginga Frank E J Coenjaerts

Cryptococcal infections are often characterized by a paucity of leukocytes in the infected tissues. Previous research has shown that the capsular polysaccharide glucuronoxylomannan (GXM) inhibits leukocyte migration. In this study we investigated whether the capsular polysaccharide GXM affects the migration of neutrophils (polymorphonuclear leukocytes [PMN]) through the endothelium by interferi...

Journal: :The Journal of infectious diseases 2005
Claudia Monari Francesco Bistoni Arturo Casadevall Eva Pericolini Donatella Pietrella Thomas R Kozel Anna Vecchiarelli

Glucuronoxylomannan (GXM) is a microbial compound that can modulate the immune response. We investigated (1) the receptors involved in uptake of GXM on monocyte-derived macrophages (MDMs) from healthy donors, (2) the effects of GXM on expression of specific receptors, (3) the effects of GXM mediated by pattern-recognition receptors, and (4) GXM modulation of MDM accessory and secretory function...

Journal: :Journal of immunology 2004
Pauline M Ellerbroek Dirk J Lefeber Richard van Veghel Jelle Scharringa Ellen Brouwer Gerrit J Gerwig Guilhem Janbon Andy I M Hoepelman Frank E J Coenjaerts

The capsular polysaccharide glucuronoxylomannan (GXM) of Cryptococcus neoformans has been shown to interfere with neutrophil migration. Although several receptors have been implied to mediate this process, the structural perspectives are unknown. Here, we assess the contribution of 6-O-acetylation and xylose substitution of the (1-->3)-alpha-d-mannan backbone of GXM, the variable structural fea...

Journal: :Eukaryotic cell 2012
Caroline L Ramos Fernanda L Fonseca Jessica Rodrigues Allan J Guimarães Leonardo P Cinelli Kildare Miranda Leonardo Nimrichter Arturo Casadevall Luiz R Travassos Marcio L Rodrigues

In prior studies, we demonstrated that glucuronoxylomannan (GXM), the major capsular polysaccharide of the fungal pathogen Cryptococcus neoformans, interacts with chitin oligomers at the cell wall-capsule interface. The structural determinants regulating these carbohydrate-carbohydrate interactions, as well as the functions of these structures, have remained unknown. In this study, we demonstra...

Journal: :Infection and immunity 2006
Zong Liang Chang Dale Netski Peter Thorkildson Thomas R Kozel

Glucuronoxylomannan (GXM), the major component of the capsular polysaccharide of Cryptococcus neoformans, is essential to virulence of the yeast. Previous studies found that the interaction between GXM and phagocytic cells has biological consequences that may contribute to the pathogenesis of cryptococcosis. We found that GXM binds to and is taken up by murine peritoneal macrophages. Uptake is ...

2017
Steven T Denham Surbhi Verma Raymond C Reynolds Colleen L Worne Joshua M Daugherty Thomas E Lane Jessica C S Brown

Cryptococcus neoformans is a common environmental yeast and opportunistic pathogen responsible for 15% of AIDS-related deaths worldwide. Mortality primarily results from meningoencephalitis, which occurs when fungal cells disseminate to the brain from the initial pulmonary infection site. A key C. neoformans virulence trait is the polysaccharide capsule. Capsule shields C. neoformans from immun...

Journal: :The Journal of biological chemistry 2006
Diane C McFadden Magdia De Jesus Arturo Casadevall

The most distinctive feature of the human pathogenic fungus is a polysaccharide capsule that is essential for virulence and is composed primarily of glucuronoxylomannan (GXM) and galactoxylomannan (GalXM). GXM mediates multiple deleterious effects on host immune function, yet relatively little is known about its physical properties. The average mass of Cryptococcus neoformans GXM from four anti...

Journal: :Infection and immunity 2005
Lauren E Yauch Michael K Mansour Stuart M Levitz

Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant m...

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