Monosodium glutamate (MSG) is a flavor enhancer and food additive with unique umami taste. Due to its widespread use in humans, this study focused on the cytotoxicity, anti-diabetic effect, interaction protein digestion by performing standardized static vitro model lipid estimating free fatty acids released from 0.5 g of olive oil during intestinal lipolysis. The showed that monosodium has an a...

Oxidative stress, which is one of the main harmful mechanisms pathologies including ischemic stroke, contributes to both neurons and endothelial cell damages, leading vascular lesions. Although many antioxidants are tested in preclinical studies, no treatment currently available for stroke patients. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, objective dev...

objective(s) the aim of this study was to evaluate the effects of dexamethasone on striatal dopaminergic, glutamatergic and gamma amino butyric acid (gaba) ergic neurotransmission in normal and parkinsonian rats. materials and methods dexamethasone (0.15, 0.30, 0.60 and 0.8 mg/kg) was administered to normal or parkinsonian rats (i.p.) followed by the analysis of the striatal neurotransmitters c...

how to cite this article: ghanizadeh a, berk m. beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature. iran j child neurol. 2015 winter;9(1):99-102. abstract autism is a disorder of unknown etiology. there are few fda approved medications for treating autism. co-occurring autism and epilepsy is common, and glutamate antagoni...

Licochalcone A (Lico A) exhibits various biological properties, including anti-inflammatory and antioxidant activities. In this study, we investigated the antioxidative potential and mechanisms of Lico A against tert-butyl hydroperoxide- (t-BHP-) induced oxidative damage in RAW 264.7 cells. Our results indicated that Lico A significantly inhibited t-BHP-induced cytotoxicity, apoptosis, and reac...

Introduction: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Regarding the role of glutamate in dentate gyrus on learning and memory, in this study the effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus was assessed. Materials and methods: In this study 20 female and 8 male rats were addic...

Bipolar disorder (BD), one of the most debilitating mental disorders, is associated with increased morbidity and mortality. Lithium is the first line of treatment option for BD and is often used for maintenance therapy. Recently, the neuroprotective action of lithium has gained tremendous attention, given that BD is associated with structural and functional abnormalities of the brain. However, ...