BACKGROUND We have recently demonstrated that activity of red blood cell glutathione peroxidase-1 is inversely associated with the risk of cardiovascular events in patients with coronary artery disease. The present study analyzed the effect of glutathione peroxidase-1 deficiency on atherogenesis in the apolipoprotein E-deficient mouse. METHODS AND RESULTS Female apolipoprotein E-deficient mic...

Selenium may play a beneficial role in multi-factorial illnesses with genetic and environmental linkages via epigenetic regulation in part via glutathione peroxidase (GPx) activity. A meta-analysis was undertaken to quantify the effects of dietary selenium supplementation on the activity of overall GPx activity in different tissues and animal species and to compare the effectiveness of differen...

BACKGROUND We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis. METHODS The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry...

Epididymal glutathione peroxidase (GPX) has been suggested as a major factor in combating loss of fertility of spermatozoa due to lipid peroxidation. We report here the isolation and sequence of putative GPX cDNAs from rat (Rattus rattus) and cynomolgus-monkey (Macaca fascicularis) epididymis, which exhibit marked sequence identity with known GPXs. In both species the cDNAs encode predicted pre...

Submit Manuscript | http://medcraveonline.com Abbreviations: EMFs: Electromagnetic Fields; MWR: Microwave Radiation; NIR: Non-Ionizing Radiation; RF-EMW: Radiofrequency Electromagnetic Waves; RF: Radiofrequency; EMW: Electromagnetic Wave; SNS: Sympathetic Nervous System; PNS: Parasympathetic Nervous System; PRA: Plasma Renin Activity; AMI: Acute Myocardial Infarction; SNAP: N-AcetylSnitrosoDl-P...

BACKGROUND Major depression and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are two disorders accompanied by an upregulation of the inflammatory and oxidative and nitrosative (IO&NS) pathways and a decreased antioxidant status. Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways. METHODS This study examines whole blood glut...

Most human selenium containing proteins contain selenium in the form of the amino acid selenocysteine, which is encoded in the corresponding mRNA as a UGA codon. Only a few non-selenocysteine containing selenoproteins are present and the nature of the association with selenium is not well understood. This review focuses on two selenocysteine-containing proteins that are members of the glutathio...

Oxidative stress is one of several factors which contribute to the development of colorectal carcinogenesis. The aim of the study was an assessment of the activity of antioxidant enzymes in tumour and corresponding normal distal mucosa in a group of patients with colorectal adenocarcinoma. Samples of tumour and corresponding normal mucosa were obtained during a resection of colorectal cancer fr...

Little is known about the potential effects of glyphosate on freshwater gastropods and possible interactions between other stressors. A two-way factorial experiment was conducted to investigate temperature (20 °C/25 °C) (0 µg/L/200 µg/L) Lymnaea sp. After 21 days, antioxidant capacity (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) glutathione-S-transferase (GST)), mal...