Islet transplantation is associated with a high rate of early graft failure caused by early immune attack and poor functionality of islets. Apoptosis of islet cells appears soon after islet isolation and primarily involves the beta-cell. The purpose of this study was to determine the effect of ligation to extracellular matrix (ECM) proteins on survival of the islets of Langerhans following isle...

BACKGROUND The aim of our work was to develop and validate a reliable LC-MS/MS-based measurement procedure for the quantification of vancomycin in serum, to be applied in the context of efforts to standardize and harmonize therapeutic drug monitoring of this compound using routine assays. METHODS Sample preparation was based on protein precipitation followed by ultrafiltration. In order to mi...

Two origin of starch – maize and wheat were tested by using four non lactating cows with rumen and duodenal Tcannules in the experiment. Cr2O3 was used as a marker of nutrient flow to the duodenum. Cows were fed diets consisting of, %: forage 70, maize and/or wheat meal 27 and/or 29, soyabeanmeal 2 and vitamix S 1, on dry matter basis. Starch origin did not affect ruminal fermentation significa...

The growth of cancer cells is limited by energy supply which is regulated by the energy sensor AMP-kinase (AMPK). Hence, mimicking a low energy state may inhibit cancer growth and may be exploited in anticancer therapies. In the present study, the impact of AMPK activation on cell growth and apoptosis of DU-145 prostate cancer cells was investigat...

solitary pulmonary nodule (spn) is a frequent finding on the chest x-ray and computed tomography. nuclear medicine techniques play an important role in the diagnosis and management of spn. in the current review, we briefly will explain the different nuclear medicine modalities in this regard including positron emission tomography (pet) using 18-f-fdg, and 11-c-methionine, and single photon emis...

social anxiety disorder (sad) is the one of the most common anxiety disorders. despite its high prevalence, the disorder is still considerably undiagnosed and untreated. the disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (gaba) s...

familial hypercholesterolemia (fh) is an inherited common autosomal mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. fh is characterized by severely elevated levels of low-density lipoprotein cholesterol (ldl-c), which result in surplus deposition of cholesterol in tissues. this condition leads to premature at hero sclerosis and early-onset of coronary hear...

background and aims: chronic hbv infection is one of the most common viral infections in worldwide which many factors such as genetic factors are involved in pathogenesis of disease. gamma interferon (ifn-γ) and its receptor (infgr) play a critical role in the immune response to hbv infection. single nucleotide polymorphisms (snps) are effective on level of gene expression, the aim of this stud...

background: vitamin d plays a critical role in the regulation of growth and differentiation of squamous epithelium. the pleiotropic effects of 1,25-dihydroxyvitamin d3 [1,25(oh)2d3], include proliferative, pro-apoptotic, and pro-differentiation effects on numerous cell types. although 1,25-dihydroxyvitamin d3 is involved in the regulation and differentiation of epithelium, there is no data in t...

background: recurrent spontaneous abortion (rsa) and in vitro fertilization (ivf) failure with unknown causes are the controversial issues that are probably related to the immune system. objective: to compare circulating nk cells expressing activation and inhibition surface markers between patients with rsa and ivf failure with those of healthy multiparous and successful ivf control women, resp...