Nematodes represent a diverse phylum of both free living and parasitic species. While the species Caenorhabditis elegans is a valuable model organism, parasitic nematodes or helminths pose a serious threat to human health. Indeed, helminths cause many neglected tropical diseases that afflict humans. Nematode glycoconjugates have been implicated in evasive immunomodulation, a hallmark of nematod...

N-Acetylneuraminic acid occupies the nonreducing end of many naturally occurring glycoconjugates on the cell surface, including glycoproteins and glycolipids. The strategic location of glycoconjugates on the cell surface and the enormous structural information that they carry account for their major role in biological recognition in the control of both normal and pathological processes.[1] Whil...

Title of Dissertation: PREPARATION AND CHARACTERIZATION OF CARBOHYDRATE-FUNCTIONALIZED NANOMATERIALS FOR USE AS CELLULAR PROBES AND TARGETED DELIVERY VEHICLES Juhee Park, Doctor of Philosophy, 2008 Dissertation directed by: Professor Philip DeShong Department of Chemistry and Biochemistry Carbohydrates are the most abundant biomolecules found in living organisms. In addition to their roles such...