Background Alzheimer Disease (AD) is a common neurodegenerative disorder which the most widespread form of dementia in world. The disease characterized by amyloid-β peptides, phosphorylated tau proteins and neuroinflammation. Because late manifestation disease, it pivotal to find new biomarkers that can help detect AD earliest phases. Glycoprotein nonmetastatic melanoma protein B (GPNMB) transm...

The human cytomegalovirus (HCMV) is a global opportunistic β-herpes virus causing severe diseases in immune-compromised patients, such as malignant tumor especially those undergoing chemotherapeutic treatment. This study aimed to determine the prevalence of HCMV-DNA treatment naive cancer and after chemotherapy, compare between conventional nested PCR ELISA techniques for detection HCMV, detect...

Background: Recurrent pregnancy loss (RPL) is a common problem among couples, and acquired thrombophilia is the well-known etiology of RPL. The aim of this study was to establish the association between inherited thrombophilic gene polymorphisms and RPL. Methods: This case-control study was conducted on 50 women with unexplained RPL and 50 parous women with no history of miscarriage (age range...

The ATP-driven xenobiotic transporter P-glycoprotein is a critical element of the blood-brain barrier. To study regulation of P-glycoprotein function, we measured specific transport [(3'-oxo-4-butenyl-4-methyl-threonine(1), (valine(2)) cyclosporin (PSC833)-sensitive] of the fluorescent cyclosporin A derivative [N-epsilon(4-nitrobenzofurazan-7-yl)-D-Lys(8)]-cyclosporin A (NBDL-CSA) into the lume...

background to treat viral infection of chronic hepatitis c (chc) is a main strategy to prevent progression of liver disease, and cancer. some patients with chc have failed to respond to the common antiviral therapy in different populations. objectives in the current study it was aimed to find out the possible role of multiple drug resistance gene1 (mdr1) in non-responder patients with chc infec...

Previous publications suggest that interstitial fluid compound concentrations (C(ISF)) best determine quantitative neurotherapeutic pharmacology relationships, although confirming large animal C(ISF) remains elusive. Therefore, this work primarily evaluated using respective acute dose, rat-derived unbound brain compound concentration-to-unbound plasma compound concentration ratios (C(b,u)/C(p,u...

B virus diagnosis presents a challenge largely complicated by the asymptomatic infection of rhesus macaques, and extremely pathogenic fatal infections in humans. Humoral detection of antibodies is generally performed using whole virus antigen for which preparation requires strict biosafety measures and specialized BSL-4 facilities. As an alternative to utilizing B virus antigen, we describe the...

Two Marek's disease virus (MDV) genes, one homologous to the glycoprotein B gene of herpes simplex virus and encoding the B antigen complex and the other encoding a 38-kDa phosphorylated protein (pp38), were inserted into the fowlpox virus (FPV) genome under the control of poxvirus promoters. Randomly selected nonessential regions of FPV were used for insertion, and the vaccinia virus 7.5 kDa p...