Newly synthesized 1,4-dihydropyridine derivatives (NK-compounds) were screened to determine whether they could overcome vincristine (VCR) resistance in VCR-resistant (P388/VCR) leukemia-bearing mice. Among the 57 NK-compounds examined, six compounds had strong reversing ability (Grade A), 18 partially overcame the resistance (Grade B), and 33 did not reverse the resistance (Grade C). The abilit...

Secreted phosphoprotein 1 (SPP1) is an acidic, phosphorylated glycoprotein found in fluids including milk and involved development of mammary gland exhibits impact on composition yield. The aim study was to reveal SPP1 gene polymorphisms association with traits Gaolao cattle. Blood collected from 280 cows test day recorded. SPP1G1-BsrI locus intron-IV polymorphic frequency TT genotype 0.99 CT 0...

BACKGROUND Human cytomegalovirus (HCMV) is a common opportunistic pathogen that causes serious complications in immunosuppressed patients and infected newborns. In this study, PCR-ELISA was optimized for semi-quantitative detection of infection in clinical specimens and simultaneous genotyping of glycoprotein B for 4 major genotypes, due to its significance. METHOD During DIG-labeling PCR, a ...