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Glycyrrhetinic acid (GA) and its related compounds are known to have anti-inflammatory activity and also to inhibit liver carcinogenesis and tumor growth. GA and related compounds inhibited cell proliferation of the human hepatoma cell line, HepG2. Among five compounds tested, ursolic acid and 18beta-olean-12-ene-3beta, 23, 28-triol (18beta-erythrotriol) were comparatively effective, where the ...

A hexane extract of Plantago major was investigated by bioactivity-directed fractionation, using an in vitro cyclooxygenase-2 (COX-2) catalyzed prostaglandin biosynthesis inhibition assay, and resulted in the isolation of ursolic acid (1). This triterpenoid showed a significant COX-2 inhibitory effect, directly on the enzyme activity, with an IC50 value of 130 microM and a COX-2/COX-1 selectivi...

Background: Although both the root and rhizome of Glycyrrhiza inflata have been used as medicinal material, sales volume price its are much higher than rhizomes. Limiting growth liquorice rhizomes while improving yield quality has become an important problem. Methods: Two irrigation patterns (surface drip subsurface irrigation, i.e. DI SDI) three levels (40%-50%, 60%-70% 80%-90% maximum soil wa...