Underwood and co-workers (27) recently re ported that a number of a-ketoaldehydes and closely related compounds were active against Newcastle disease virus (NJKD strain) and in fluenza virus (PR-8 strain) in embryonated eggs. These substances also had potent virus-inactivat ing effects in vitro. Underwood and Weed (28) found that glyoxal and methylglyoxal were active virucides in blood. Consequ...

The condensation of glyoxal with benzylamine in the presence of formaldehyde leads to 2,4,6,8-Tetrabenzyl-2,4,6,8-Tetraazabicyclo [3.3.0] octan (6) in methanol. The scopes and limitations of the reaction have been determined. At low temperatures, a mixture of (6) and diol (7) is formed. 

Condensation of glyoxal, formaldehyde and anilines lead to the formation of 2,4,6,8- tetraphenyl and substituted phenyl 2,4,6,8-tetraazabicyclo [3.3.0] octanes. The reactions are sensitive to pH and temperature. Ortho derivatives of anilines do not participate in this condensation. X-ray structural determination reveals a cis-dienvelope geometery about the two fused rings.

condensation of glyoxal, formaldehyde and anilines lead to the formation of 2,4,6,8- tetraphenyl and substituted phenyl 2,4,6,8-tetraazabicyclo [3.3.0] octanes. the reactions are sensitive to ph and temperature. ortho derivatives of anilines do not participate in this condensation. x-ray structural determination reveals a cis-dienvelope geometery about the two fused rings.

the one pot reaction of glyoxal and hydroxylamine hydrochloride in aqueous sodium hydroxide was found to be a safe and inexpensive method for the preparation of diaminoglyoxime. by increasing stoichiometric ratio of the hydroxylamine hydrochloride and decreasing the solvent volume, the product yield increased considerably (~ 70%).