Bcl-2-associated athanogene 1 (Bag-1) is a positive regulator of Bcl-2 which is an anti-apoptotic gene. Bag-1 was very slightly expressed in normal tissues, but often highly expressed in many tumor tissues, particularly in colon cancer, which can promote metastasis, poor prognosis and anti-apoptotic function of colon cancer. We prepared and evaluated magnetic gold nanoparticle/Bag-1 siRNA recom...

Glyco-gold nanoparticles combine in a single entity the peculiar properties of gold nanoparticles with the biological activity of carbohydrates. The result is an exciting nanosystem, able to mimic the natural multivalent presentation of saccharide moieties and to exploit the peculiar optical properties of the metallic core. In this review, we present recent advances on glyco-gold nanoparticle a...

The interaction between localized and propagating surface plasmons is investigated in a structure consisting of a two-dimensional periodic gold nanoparticle array, an SiO2 spacer, and a gold film. The resonance wavelengths of the two types of surface plasmons supported by the structure are tailored by changing the gold nanoparticle size and the array period. An anticrossing of the resonance pos...

Here we report a real-time PCR-based method for determining the surface coverage of dithiol-capped oligonucleotides bound onto gold nanoparticles alone and in tandem with antibody. The detection of gold nanoparticle-bound DNA is accomplished by targeting the oligonucleotide with primer and probe binding sites, amplification of the oligonucleotide by PCR, and real-time measurement of the fluores...

The emission of CdSe quantum dots linked to the 5'-end of a DNA sequence is efficiently quenched by hybridisation with a complementary DNA strand with a gold nanoparticle attached at the 3'-end; contact of the quantum dot and gold nanoparticle occurs.

Nanomaterials are widely used as pseudostationary and stationary phases in electrically driven separations. The advantages of using nanomaterials are numerous including tunable sizes, multiple core compositions, flexible injection schemes, and diverse surface chemistries. Nanomaterials, however, exhibit large surface energies which induce aggregation and may yield unpredictable function in sepa...

We have developed a colloidal assembly for the study of plasmon–plasmon interactions between gold nanoparticles. Colloidal aggregates of controlled size and interparticle spacing were synthesized on silica nanoparticle substrates. Following the immobilization of isolated gold nanoparticles onto silica nanoparticles, the surfaces of the adsorbed gold nanoparticles were functionalized with 4-amin...

Water dispersible single- and bilayered graphene sheets are produced by a direct exfoliation from graphite flakes in the presence of pyrene-labeled single stranded DNAs, and the immobilized DNA on the graphene surface is further hybridized with a gold nanoparticle labeled complementary DNA to generate gold nanoparticle-graphene nanocomposites.

Melting and hybridization of DNA-capped gold nanoparticle networks are investigated with optical absorption spectroscopy. Single-stranded, 12-base DNA-capped gold nanoparticles are linked with complementary, single-stranded, 24-base linker DNA to form particle networks. Compared to free DNA, a sharp melting transition is seen in these networked DNA-nanoparticle systems. The sharpness is explain...

This article explores the novel gold nanoparticle-enhanced photodynamic therapy of methylene blue against recalcitrant pathogenic Candida albicans biofilm. Physiochemical (X-ray diffraction, ultraviolet-visible absorption, photon cross-correlation, FTIR, and fluorescence spectroscopy) and electron microscopy techniques were used to characterize gold nanoparticles as well as gold nanoparticle-me...