Age-specific incidence of epithelial ovarian cancer indicates a hormonal etiology and relates it to menopause, a time during the aging process when ovaries fail but the pituitary becomes overactive to produce a greater amount of gonadotropins. There is a 10-fold to 20-fold increase in the follicle-stimulating hormone (FSH) level and a 3-fold to 5-fold increase in the luteinizing hormone (LH) le...

background: different protocols are used for controlled ovarian hyper stimulation (coh), but the optimal method has not yet been determined. objective: the aim of this study was to compare the outcome of controlled ovarian stimulation (cos) using clomiphen citrate (cc) plus hmg versus cc plus rfsh in intra uterine insemination cycles (iui). materials and methods: 144 women with unexplained or m...

ObjectiveTo evaluate the evidence addressing association between use of ovarian stimulation drugs and risk breast cancer.DesignSystematic review meta-analysis.SettingNot applicable.Patient(s)Women without any previous history cancer undergoing stimulation.Intervention(s)Electronic databases were searched from 1990 until January 2020. All cohort studies reporting new incidences in infertile wome...

Anovulatory disorders are a primary cause of female infertility. Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity. Lifestyle changes to encourage weight loss are the initial therapy for overweight and obese patients, followed by clomiphene citrate for ovulation induction. For those patients who fail to ovulate on clomiphene citrate, alternat...

GnRH is potent stimulator of gonadotropin's alpha and beta chains synthesis in vivo. Stimulation of LH beta gene transcription requires pulsatile GnRH administration but the transcription of alpha subunit can be stimulated independently of GnRH mode of administration. Castration increases whereas in vivo estradiol and testosterone replacement decreases the rate of gene transcription of pituitar...