We studied the role of the adenylyl cyclase ACA in Dictyostelium discoideum chemotaxis and streaming. In this process, cells orient themselves in a head to tail fashion as they are migrating to form aggregates. We show that cells lacking ACA are capable of moving up a chemoattractant gradient, but are unable to stream. Imaging of ACA-YFP reveals plasma membrane labeling highly enriched at the u...

Box H/ACA small nucleolar ribonucleoprotein particles (H/ACA snoRNPs) play key roles in the synthesis of eukaryotic ribosomes. The ways in which these particles are assembled and correctly localized in the dense fibrillar component of the nucleolus remain largely unknown. Recently, the essential Saccharomyces cerevisiae Naf1p protein (encoded by the YNL124W open reading frame) was found to inte...

The ability of a cell to detect an external chemical signal and initiate a program of directed migration along a gradient comprises the fundamental process called chemotaxis. Investigations in Dictyostelium discoideum and neutrophils have established that pleckstrin homology (PH) domain-containing proteins that bind to the PI3K products PI(3,4)P2 and PI(3,4,5)P3, such as CRAC (cytosolic regulat...

objective: the morphology of anterior cerebral artery (aca) in patients with hydrocephalus was analyzed (hcp), and its importance was discussed in maintaining cerebral perfusion. materials & methods: two groups were created for the study. group 1; patients with hydrocephalus and group 2; as control group without hcp. in both groups, the length of the a2 segment of aca was measured from its orig...

Ant colony algorithm (ACA), inspired by the food-searching behavior of ants, is an evolutionary algorithm and performs well in discrete optimization. In this paper, it is used for fuzzy clustering in image segmentation. Three features such as gray value, gradient and neighborhood of the pixels, are extracted for the searching and clustering process. Unexpectedly, tests show that it is time cons...

The understanding of the effect generated by small differences organic ligands on molecular and supramolecular arrangement coordination polymers (CPs) is a key factor to control their properties. Therefore, study structurally related differing in some factors inter alia functional group orientation, length, or functionality crucial task for crystal engineers. In this contribution, reactions bet...

PURPOSE The purpose of this investigation was to determine the antileukemic effects of 1'-acetoxychavicol acetate (ACA) obtained from rhizomes of the commonly used ethno-medicinal plant Languas galanga (Zingiberaceae). EXPERIMENTAL DESIGN We evaluated the effects of ACA on various myeloid leukemic cells in vitro and in vivo. We further examined the molecular mechanisms of ACA-induced apoptosi...

BACKGROUND To clarify the clinicopathological characteristics of primary Sjögren's syndrome (pSS) with anti-centromere antibody (ACA). METHODS Characteristics of 14 patients of pSS with ACA were evaluated. All patients were anti-SS-A/Ro and SS-B/La antibodies negative (ACA+ group) without sclerodactyly. The prevalence of Raynaud's phenomenon (RP), titer of IgG and focus score (FS) in the mino...