The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD341 progenitor cells are treated with granulocyte-macrophage colonystimulating factor (GM-CSF)/tumor necrosis factor (TNF) 6 stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokine exposure, DC development is halted and myelogranulocytic hematopoiesis takes plac...

conclusions the present study showed that g-csf is not superior to placebo in production of protective antibody titers after hbv vaccination but could result in a more rapid antibody response, compared to the placebo. results there was no statistically significant difference between anti-hbv antibody titers in patients receiving double dose hbv vaccination plus g-csf and patients receiving doub...

BACKGROUND Following the release of the initial presentation of filgrastim (granulocyte colony-stimulating factor), several biosimilars have been developed worldwide. OBJECTIVE To study the efficacy of a Mexican biosimilar granulocyte colony-stimulating factor in a single transplant center. METHODS In a group of 19 consecutive patients with multiple sclerosis given autografts, we employed g...

In the background section of their abstract, Woei-Cherng Shyu and associates state that because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and the capacity to mobilize stem cells, it has the potential to be used in treatment of stroke. However, there are limited data about the effects of G-CSF on hemostasis. It has been suggested that G-CS...

OBJECTIVES/HYPOTHESIS Granulocyte/macrophage colony-stimulating factor is important in the pathogenesis of acute and chronic inflammatory disease. We hypothesized that granulocyte/macrophage colony-stimulating factor plays a pivotal role in middle ear inflammation and that neutralization of granulocyte/macrophage colony-stimulating factor would inhibit neutrophil migration into the middle ear a...

Neutropenia is common in the practice of both primary care physicians and sub-speciality. Congenital neutropenia are rare diseases; they can be isolated independent diseases accompany a number other inborn errors immunity. The clinical course range from asymptomatic patients with mild to life-threatening infections cases severe neutropenia. Treatment congenital remains discutable this day. most...

Granulocyte colony-stimulating factor was discovered during attempts to define the normal regulators present in cell supernatants that could induce terminal differentiation of the murine myeloid leukemic cell line WEHI-3B D+. The purification and subsequent cloning of both murine and human G-CSF allowed the normal functions of this molecule to be elucidated and indicated that it was a relativel...