This study measured the effect of media exposure on grapefruit/grapefruit juice consumption changes, in particular grapefruit-medicine interaction. Respondents' attitudes about health news on television and the internet were measured to account for consumers exposed versus not exposed to such information. Results of a sample selection model show that consumer attitudes toward health news were s...

4. Rouse, A. H., C. D. Atkins and R. L. Huggart. 1954. Effect of pulp quantity on chemical and physi cal properties of citrus juices and concentrates. Food Technol. 8: 431-435. 5. U. S. Dept. Agriculture. U. S. standards for grades of canned citrus juices and concentrates. Agricultural Marketing Service, Washington, D. C: (a) Frozen concentrated grapefruit juice, Dec. 1951; (b) Frozen concentra...

background: recently grapefruit juice is known to enhance the bioavailability of several clinically important drugs such as nifedipine, terfenadine, cyclosporine, ethinylestradiole, midazolam, and triazolam. cyclosporine is an immunosuppressive agent that used in transplantation for preventation of chronic rejection. grapefruit increase in cmax and auc of drug mediated by suppression of cyp3a4 ...

Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism through the intestinal cytochrome P450 3A4 system, low bioavailability, and a narrow therapeutic index. Pro...

A clinical study was performed in eight healthy volunteers to investigate the effect of various timing of grapefruit juice intake on nisoldipine pharmacokinetics and pharmacodynamics, and to validate our pharmacokinetic model. The subjects were given 10 mg oral nisoldipine with water (control), or 5 mg oral nisoldipine with 200 mL grapefruit juice (G0) or with water at 14 (G14), 38 (G38), 72 (G...

Distribution of radiolabeled assimilates was examined at various intervals after 1 hour of light or dark 14CO2 fixation by leaves or developing fruit of grapefruit (Citrus paradisi Macf.) so that the fate of assimilates from each source could be assessed at sequential stages of fruit growth. Exported products of both light and dark 14CO2 fixation in leaves were deposited primarily in juice tiss...

The increase in oral availability of felodipine and other commonly used medications when taken with grapefruit juice has been assumed to be due to inhibition of CYP3A4, a cytochrome P450 that is present in liver and intestine. To evaluate the effect of repeated grapefruit juice ingestion on CYP3A4 expression, 10 healthy men were given 8 oz of grapefruit juice three times a day for 6 d. Before a...