The overall goal of this dissertation project was to characterize the impact of ulceration on propulsive motility in guinea pig tri-nitro benzene sulfonic acid (TNBS) colitis. The study was comprised of three aims: to determine how ulceration affects motility; to examine changes in neural control of muscle contractility; and to test whether there is a relationship between previously identified ...

Most regions of the gastrointestinal tract generate spontaneous electrical and mechanical activity in the absence of stimulation. When electrical recordings are made from slow muscle cells lying in the gastrointestinal tract, a regular discharge of long lasting waves of depolarization, slow waves, is detected. It has recently become apparent that slow waves are generated by a specialized popula...

Gastric stromal tumor (GST) is a set of gastrointestinal mesenchymal tumors those originate from interstitial cells of Cajal. Its early diagnosis and treatment are critical to prognosis.[1] The occurrence of GST remains obscure; this study used Affymetrix expression spectrum chip to detect the gene expression spectrum of GST and explore new molecular target that is used in the treatment and pro...

Diabetes mellitus is a symptom that can be characterized by chronic hyperglycemia and impaired metabolism of carbohydrates, fats and proteins associated with the lack of insulin secretion or insulin action both in absolute and relative terms. Treatment with drugs distributed on the market either relatively more expensive because of its use in the long term or have considerable side effects. Pre...

TO THE EDITOR: I read the report entitled “Do HbA1C levels correlate with delayed gastric emptying in diabetic patients?” by Reddy et al with great interest. The authors investigated the relationship between serum HbA1C and gastric emptying (GE), assessed by gastric emptying scintigraphy, in diabetics. Based on the data, the authors suggest that HbA1C is not as important as daily glycemic contr...

objective(s): bidens species are used for their antidiabetic properties traditionally in many countries. aim of this study is to evaluate hypoglycaemic and antidiabetic activity of bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. materials and methods: hypoglycaemic effects of b. tripartita extract and its sub-extracts were investiga...

Phytochemical investigation of the roots of Salsola imbricata allowed to two new bioactive biphenylpropanoids (1) and (2) named, biphenylsalsonoid A and B, respectively. Their structures were established through spectroscopic methods (1D and 2D NMR, (ES)-HRMS, and IR). The isolates were tested for their antioxidant activity using DPPH• and ABTS•+ assays. 1 and 2 showed a moderate activity towar...

Diabetic peristalsis disorders are common complications in diabetes mellitus type 2. Disturbance of interstitial cells Cajal (ICC) caused by metabolic changes could explain the symptoms diabetic gastroenteropathy. Although heterogenous cell types represent only 5% population muscle layer gastrointestinal tract (GIT), they important for conducting electrical signals and regulating excitability. ...