Functional dyspepsia and gastroparesis represent the most common sensory-motor disorders of upper gastrointestinal tract. Scientific advances in last decade have shown that there is significant overlap between them. This review aims to address current knowledge about their pathophysiology, diagnosis treatment. a medical condition characterized by one or more following symptoms: early satiety, p...

1. Gastrointestinal Physiology 1.1. Smooth muscle cell electrophysiology 1.2. Electrophysiology of the interstitial cells of Cajal 1.3. Motility-related gastric disorders 2. Mathematical models of the gastrointestinal system 2.1. Electrophysiological cell models 2.1.1. Phenomenological cell models 2.1.2. Biophysically-based cell models 2.2 Tissue and organ models 2.2.1. Monodomain model 2.2.2. ...

OBJECTIVE To evaluate the antihyperglycemic activity of ethyl acetate extract of Hypericum perforatum (H. perforatum) in streptozotocin (STZ)-induced diabetic rats. METHODS Acute toxicity and oral glucose tolerance test were performed in normal rats. Male albino rats were rendered diabetic by STZ (40 mg/kg, intraperitoneally). H. perforatum ethyl acetate extract was orally administered to dia...

Background: It is pertinent to objectively assess the severity of diabetic gastroparesis and tailor treatment accordingly. The current study was planned to document gastroparesis by gastric emptying scintigraphy (GES) objectively and see the effect of medications and diet control on clinical and GES after four weeks. Methods: A prospective, open-label randomized trial was conducted in the Depa...

Interstitial cells of Cajal (ICC) are the pacemaker cells in the gut. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal muscles. The electrical slow wave activity determines the characteristic frequency of phasic contractions of the stomach, intestine and colon. Slow waves also determine the direction and velocity of pro...

OBJECTIVE Delayed gastric emptying and/or gastrointestinal symptoms occur in 30-50% of diabetic patients. Known contributing factors are autonomic neuropathy and acute hyperglycemia, but the role of gastric autoimmunity has never been investigated, although 15-20% of type 1 diabetic patients exhibit parietal cell antibodies (PCAs). We studied gastric motility in diabetes in relation to PCA stat...

Background. Electroacupuncture (EA) at ST36 has been used to regulate gastric motility and effectively improve gastric emptying in diabetic patients. Nevertheless, the specific mechanisms underlying the efficacy of this treatment remain unknown. The aim of this study was to assess the variations of interstitial cells of Cajal (ICC) and explore the changes in mSCF/KIT-ETV1 signaling in the antru...

BACKGROUND To differentiate gastric motility and sensation between type II diabetic patients and controls and explore different expressions of gastric motility peptides. METHODS Eleven type II diabetic patients and health volunteers of similar age and body mass index were invited. All underwent transabdominal ultrasound for gastric motility and visual analogue scales. Blood samples were taken...