Understanding the underlying pleiotropic relationships among growth and body size traits is important for refining breeding strategies in dairy cattle optimal rate. Therefore, we performed single-trait genome-wide association studies (GWAS) monthly-recorded weight (BW), hip height (HH), length (BL) chest girth (CG) from birth to 12 mo of age Holstein animals, followed by stepwise multiple regre...

2009 will be remembered as the year that genome-wide association studies (GWAS) revealed both their promise and limitations as an approach to understand the genetic architecture of stroke. The promise of GWAS lies in their extraordinary power to detect novel biologic loci that, if replicated, can serve as markers for novel genes, proteins, and ultimately mechanisms of disease. In this regard, s...

Refractive error (RE) is a complex multifactorial disease. Genome-wide association studies (GWAS) have provided significant insight into the genetic architecture and identified plenty of robust genetic variations or single nucleotide polymorphisms (SNPs) associated with complex disease. A major current challenge is to convert those resources into causal variants and target genes. We used Regulo...

This experimental study was conducted with completely randomized design. Genome-wide association studies (GWAS) have revealed a large number of genetic associations of nucleotide sequence variants with susceptibility to multiple sclerosis (MS). Nevertheless, studies to identify the functional relevance of these variants lag far behind identification of the GWAS signals. Expression quantitative ...

The abundance of high-quality genotype and phenotype data for the model organism Arabidopsis thaliana enables scientists to study the genetic architecture of many complex traits at an unprecedented level of detail using genome-wide association studies (GWAS). GWAS have been a great success in A. thaliana and many SNP-trait associations have been published. With the AraGWAS Catalog (https://arag...

BACKGROUND We describe SNPpy, a hybrid script database system using the Python SQLAlchemy library coupled with the PostgreSQL database to manage genotype data from Genome-Wide Association Studies (GWAS). This system makes it possible to merge study data with HapMap data and merge across studies for meta-analyses, including data filtering based on the values of phenotype and Single-Nucleotide Po...