A DNA haplotype system combines information from two or more distinct polymorphic systems located within a small length of DNA in which there is little recombination. Each possible combination of alleles, one from each component system, constitutes a distinct haplotype that is treated as an allele of the haplotype system. Combining the information from several polymorphic systems (such as RFLPs...

A haplotype in the gene for transient receptor potential cation channel, subfamily C, member 4 associated protein (TRPC4AP), has been identified in two extended pedigrees with late-onset Alzheimer's disease. Nine of the SNPs in the haplotype were analyzed in our unrelated Alzheimer's patients and controls. The H1 haplotype was found in 36% of the patients (199 patients) and in 26% of the contro...

The sex-related spatial genetic structure of a free-living population of the common vole (Microtus arvalis) was assessed using sequence and haplotype frequency data of the complete mitochondrial cytb gene in three seasons. Six haplotypes were resolved, three of them (A, B and C) were shared among seasons and sexes. The remaining three singletons did not match any of the local females. Pairwise ...

Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n = 123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n = 5,243 (region 9) to n = 19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in r...

Studies suggest that underglycosylation of the cell membrane mucin MUC1 may be associated with epithelial ovarian cancer. We identified 26 genes involved in glycosylation and examined 93 single nucleotide polymorphisms (SNP) with a minor allele frequency of > or =0.05 in relation to incident ovarian cancer. Cases were ascertained at the Mayo Clinic, Rochester, MN (n = 396) or a 48-county region...

The majority of killer cell immunoglobin-like receptor (KIR) genes are detected as either present or absent using locus-specific genotyping technology. Ambiguity arises from the presence of a specific KIR gene since the exact copy number (one or two) of that gene is unknown. Therefore, haplotype inference for these genes is becoming more challenging due to such large portion of missing informat...

Chloroplast DNA (cpDNA) inheritance was investigated in Sorbus aucuparia using progenies obtained from six controlled crosses between individuals of known haplotype. Polymerase chain reaction (PCR) amplification, followed by restriction analysis, was used to characterize 248 offspring for either of two polymorphic cpDNA fragments. All offspring exhibited the maternal haplotype, which indicates ...

The aim of our study was to analyze the reproduction dynamics and fertility rates Ayrshire cattle population in Russia assess level influence AH1 haplotype on incidence stillbirth. For an overall estimate, we used 390,769 records 67 dairy herds from 2003 2018. Against background stable growth, average stillbirth rate 3.33% abortion 0.075%. A high percentage (5.13%) heifers first fertilization e...

Using computer simulations, we generated and analyzed genetic distances among selectively neutral haplotypes transmitted through gene genealogies with random-mating organismal pedigrees. Constraints and possible biases on haplotype distances due to correlated ancestry were evaluated by comparing observed distributions of distances to those predicted from an inbreeding theory that assumes indepe...

The somatotropic axis is a major regulatory pathway of energy metabolism during postnatal growth in mammals. Genes involved in this pathway influence many economically important traits. The association of selected SNPs in these genes with carcass traits was examined in grazing Brangus steers. These traits included final live weight, ultrasound backfat thickness (UBFT), rib-eye area, kidne...