نتایج جستجو برای: has mir 100
تعداد نتایج: 2966234 فیلتر نتایج به سال:
BACKGROUND The purpose of this study was to investigate the potential role of variable microRNA (miRNA) expression in the development of multidrug resistance (MDR) in head and neck cancer. METHODS Head and neck squamous cell carcinoma cell lines UMSCC-1 and SQ20B were treated with docetaxel at increasing concentrations to develop resistant cell lines. Parental and resistant cells were treated...
– OBJECTIVE: MicroRNAs (miRNAs) act as key regulators of diverse cellular activities by regulating the expression of proteincoding genes. Osteoblast differentiation, a fundamental step in skeletal development, involves the activation of several signaling pathways, including transforming growth factor β (TGF-β), bone morphogenetic protein (BMP), and Wnt signaling pathways. MATERIALS AND METHODS:...
زمینه و هدف: mirna های مرتبط با متاستاز حوزه جدیدی از درمان های متاستاز بر اساس mir را ایجاد کرده که پتانسیل درمانی بالایی برای کشنده ترین جنبه سرطان، یعنی متاستاز دارد. mir-31 یک mirna ضد متاستازی با عملکرد پلیوتروپیک است که بیان آن در سلول های متاستاتیک سرطان پستان به طور قابل توجهی کاهش می یابد. این mirna در چندین مرحله از آبشار متاستازی نقش دارد و استفاده از روش های بازیافت mir-31 می تواند ...
OBJECTIVE(S) Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and l...
In melanoma, the adaptative cell response to BRAF inhibitors includes altered patterns of cytokine production contributing to tumor progression and drug resistance. Among the factors produced by PLX4032-resistant melanoma cell lines, CCL2 was higher compared to the sensitive parental cell lines and increased upon drug treatment. CCL2 acted as an autocrine growth factor for melanoma cells, stimu...
The aim of this study was to determine, in vitro, the effects of X4 and R5 HIV-1 gp120 and Tat on: (1) endothelial cell senescence and (2) endothelial cell microRNA (miR) expression. Endothelial cells were treated with media without and with: R5 gp120 (100 ng/mL), X4 gp120 (100 ng/mL), or Tat (500 ng/mL) for 24 h and stained for senescence-associated β-galactosidase (SA-β-gal). Cell expression ...
miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma
Osteosarcoma is the most common primary malignancy in bone. Patients who respond poorly to induction chemotherapy are at higher risk of adverse prognosis. The molecular basis for such poor prognosis remains unclear. We investigated miRNA expression in eight open biopsy samples to identify miRNAs predictive of response to induction chemotherapy and thus maybe used for risk stratification therapy...
Mir Ali Heravi (died in 1545) is one of the greatest masters in Nasta’liq script who was famous and popular while he was alive among Uzbek, Indian and Ottoman governors. Majnoun Rafiqi is also one of the poets and calligraphers who is contemporary with Mir Ali and has written three treatises about teaching calligraphy. He was famous in his own period of time but since he did not have well-known...
Mir Ali Heravi (died in 1545) is one of the greatest masters in Nasta’liq script who was famous and popular while he was alive among Uzbek, Indian and Ottoman governors. Majnoun Rafiqi is also one of the poets and calligraphers who is contemporary with Mir Ali and has written three treatises about teaching calligraphy. He was famous in his own period of time but since he did not have well-known...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید