نتایج جستجو برای: hbm

تعداد نتایج: 1007  

Journal: :Pediatric dentistry 1999
P R Erickson E Mazhari

PURPOSE The objective of this study was to determine the caries-related risk associated with human breast milk (HBM). METHODS First, the plaque pH of 18 children (12-24 months) was monitored before and after a five-minute feeding with HBM to determine the pH drop and minimum pH obtained. Second, Streptococcus sobrinus 6715 was cultured for 3 hr in HBM, and the increase in the number of colony...

2016
Zhengji Zhao Martijn Marsman

NERSC is preparing for its next petascale system, named Cori, a Cray XC system based on the Intel KNL MIC architecture. Each Cori node will have 72 cores (288 threads), 512 bit vector units, and a low capacity (16GB) and high bandwidth (~5x DDR4) on-package memory (MCDRAM or HBM). To help applications get ready for Cori, NERSC has developed optimization strategies that focus on the MPI+OpenMP p...

2011
Yuan-Ta Lin Yijuang Chern Che-Kun James Shen Hsin-Lan Wen Ya-Chin Chang Hung Li Tzu-Hao Cheng Hsiu Mei Hsieh-Li

We investigated the therapeutic potential of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in Huntington's disease (HD) mouse models. Ten weeks after intrastriatal injection of quinolinic acid (QA), mice that received hBM-MSC transplantation showed a significant reduction in motor function impairment and increased survival rate. Transplanted hBM-MSCs were capable of survival, and ...

2016
Celia L Gregson Lawrie Wheeler Sarah A Hardcastle Louise H Appleton Kathryn A Addison Marieke Brugmans Graeme R Clark Kate A Ward Margaret Paggiosi Mike Stone Joegi Thomas Rohan Agarwal Kenneth ES Poole Eugene McCloskey William D Fraser Eleanor Williams Alex N Bullock George Davey Smith Matthew A Brown Jon H Tobias Emma L Duncan

High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM disorders (eg, LRP5 or SOST mutations) are rare. We aimed to determine to what extent HBM is explained by mutations in known HBM genes. A total of 258 unrelated HBM cases were identified from a review of 335,115 DXA scans from 13 UK centers. Cases were assessed clinically and underwent sequencing of known anaboli...

2017
Shufeng Zhou Renzo Cecere Anie Philip

Although there is increasing evidence that human bone marrow mesenchymal stem cells (hBM-MSCs) play an important role in cancer progression, the underlying mechanisms are poorly understood. Transforming growth factor β (TGF-β) is an important pro-metastatic cytokine. We have previously shown that CD109, a glycosylphosphatidylinositol-anchored protein, is a TGF-β co-receptor and a strong inhibit...

2016
Paul Takam Kamga Giulio Bassi Adriana Cassaro Martina Midolo Mariano Di Trapani Alessandro Gatti Roberta Carusone Federica Resci Omar Perbellini Michele Gottardi Massimiliano Bonifacio Armel Hervé Nwabo Kamdje Achille Ambrosetti Mauro Krampera

Both preclinical and clinical investigations suggest that Notch signalling is critical for the development of many cancers and for their response to chemotherapy. We previously showed that Notch inhibition abrogates stromal-induced chemoresistance in lymphoid neoplasms. However, the role of Notch in acute myeloid leukemia (AML) and its contribution to the crosstalk between leukemia cells and bo...

Journal: :Cognition 2012
Katya Tentori Vincenzo Crupi

In this paper we question the theoretical tenability of Hertwig, Benz, and Krauss's (2008) (HBK) argument that responses commonly taken as manifestations of the conjunction fallacy should be instead considered as reflecting "reasonable pragmatic and semantic inferences" because the meaning of and does not always coincide with that of the logical operator ∧. We also question the relevance of the...

2016
Tae Hwan Shin Geetika Phukan Jeom Soon Shim Duc-Toan Nguyen Yongman Kim Justin D. Oh-Lee Hyeon-Seong Lee Man Jeong Paik Gwang Lee

We investigated changes in PA levels by the treatment of human bone-marrow-derived mesenchymal stem cells (hBM-MSCs) in ischemic stroke in rat brain model and in cultured neuronal SH-SY5Y cells exposed to oxygen-glucose deprivation (OGD). In ischemic rat model, transient middle cerebral artery occlusion (MCAo) was performed for 2 h, followed by intravenous transplantation of hBM-MSCs or phospha...

Journal: :Oncology reports 2016
Chengcheng Xia Pengyu Chang Yuyu Zhang Weiyan Shi Bin Liu Lijuan Ding Min Liu Ling Gao Lihua Dong

Radiation-induced lung injury (RILI) is a fatal condition featured by interstitial pneumonitis and fibrosis. Mesenchymal stem cells (MSCs) have been widely used for treating RILI in rodent models. In the present study, we aimed to investigate whether the therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) on RILI were in a dose-dependent manner. A total of 100 mic...

2014
Celia L. Gregson Kenneth E. S. Poole Eugene V. McCloskey Emma L. Duncan Jörn Rittweger William D. Fraser George Davey Smith Jonathan H. Tobias

CONTEXT The role and importance of circulating sclerostin is poorly understood. High bone mass (HBM) caused by activating LRP5 mutations has been reported to be associated with increased plasma sclerostin concentrations; whether the same applies to HBM due to other causes is unknown. OBJECTIVE Our objective was to determine circulating sclerostin concentrations in HBM. DESIGN AND PARTICIPAN...

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