BACKGROUND Serum HBV RNA is detectable during nucleoside/nucleotide analogue therapy as a result of unaffected RNA replicative intermediates or interrupted reverse transcription. We studied the predictive value of serum HBV RNA for initial virological response during nucleoside analogue therapy. METHODS Serum HBV RNA was quantified before and at 12 and 24 weeks of lamivudine or entecavir ther...

Abstract Hepatitis B virus infection is perilous among the five types of Hepatitis, as it remains clinically asymptomatic. The present study draws up-to-date prevalence (HBV) in general population Mardan, Khyber Pakhtunkhwa Pakistan. blood samples from 4803 individuals including 2399 male and 2404 females were investigated. All suspected analyzed for hepatitis surface antigen using Immuno-chrom...

Hepatitis B virus (HBV) and hepatitis delta virus (HDV) interplay was investigated by examining liver and serum samples from 21 coinfected and 22 HBV-monoinfected patients with chronic liver disease. Different real-time PCR assays were applied to evaluate intrahepatic amounts of HBV DNA, covalently closed circular DNA (cccDNA), pregenomic RNA (pgRNA), pre-S/S RNAs, and HDV RNA. Besides HBV DNA ...

BACKGROUND The hepatitis B virus (HBV) infection could activate the immune system and induce extensive inflammatory response. As the most important inflammatory factor, interleukins are critical for anti-viral immunity. Here we investigated whether interleukin-34 (IL-34) play a role in HBV infection. METHODOLOGY/PRINCIPAL FINDINGS In this study, we first found that both serum IL-34 and IL-34 ...

BACKGROUND Reactivation of HBV replication is a clinically significant complication in HBV(+) patients receiving chemotherapy. We recently found that nearly half of the HBV reactivation in lymphoma patients occurred within 2 weeks of the first dose of chemotherapy. We hypothesized that mechanisms other than immunosuppression, such as direct stimulation of HBV replication by anticancer drugs, mi...

Infekce virem hepatitidy B (HBV) je stále celosvětově zdravotním problém s měnící se epidemiologií v závislosti na řadě faktorů, především vakcinační politice a migraci. Chronická infekce HBV dynamický proces, který odráží interakce mezi virovou replikací hostitelskou imunitní odpovědí. Ne všichni pacienti chronicky infikovaní mají chronickou hepatitidu B. Ukonče...

This paper deals with a fractional optimal control problem model that describes the interactions between hepatitis B virus (HBV) HBV DNA-containing capsids, liver cells (hepatocytes), and cytotoxic T-cell immune response. Optimal controls represent effectiveness of drug therapy in inhibiting viral production preventing new infections. The optimality system is derived solved numerically. Our res...

BACKGROUND This study aimed to investigate the relationships of intrahepatic cccDNA with serum HBsAg and with HBV DNA in treatment-naive patients throughout acute and chronic HBV infection. METHODS A total of 120 patients who had a liver biopsy were enrolled, including 19 with acute hepatitis B (AHB), and 101 patients with chronic HBV infection (CHB) of whom were 10 in immune-tolerant (IT) ph...

Recovery from an acute hepatitis B virus (HBV) infection is associated with loss of HBV DNA from serum, hepatitis B e antigen seroconversion, hepatitis B surface antigen (HBsAg) seroconversion, and normalization of serum aminotransferases. These changes generally imply clearance of virus, but clinical observations have shown that reactivation of HBV infection can occur either spontaneously or a...