Although the age-adjusted mortality from heart disease has declined in the United States, cardiovascular disease remains the No. 1 cause of death.1,2 Patients with cardiac disease generally die of one of 2 causes: sudden, unexpected cardiac death or progressive heart failure. Chronic heart failure (CHF) has become an epidemic in the United States. Implantable cardioverter-defibrillator (ICD) th...

Significance: Cell senescence was originally defined by an acute loss of replicative capacity and thus believed to be restricted proliferation-competent cells. More recently, has been recognized as a cellular stress damage response encompassing multiple pathways or domains, namely DNA response, cell cycle arrest, senescence-associated secretory phenotype, mitochondrial dysfunction, autophagy/mi...

In most adult cardiac surgery operations, the heart must be completely immobile and isolated from blood. Therefore, is stopped in diastole a still operative site obtained. Cardiac arrest results ischemia-reperfusion injury. For these reasons, myocardial protection prevention of damages are required. Various cardioplegia solutions used for this purpose. It can said that gold standard method arre...

Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients....

Warning signs frequently occur in the days and weeks before a sudden cardiac arrest but are mostly ignored, research published in the Annals of Internal Medicine has found. US researchers collected information about symptoms during the four weeks before a sudden cardiac arrest from 1099 people in the Portland, Oregon area. Information was gathered from survivors, family members, medical records...

INTRODUCTION Cardiac arrest is a common emergency in acute hospitals. The Resuscitation Council (UK) Advanced Life Support Guidelines provide a systematic approach to cardiac arrest recognition, treatment and aftercare. This review provides an update on the current treatment guidelines and identifies areas where these may be strengthened. METHODS The evidence informing the 2005 Resuscitation ...

Introduction Induction of moderate hypothermia (28°C to 32°C) before cardiac arrest has been used successfully since the 1950s to protect the brain against the global ischemia that occurs during some open-heart surgeries. Successful use of therapeutic hypothermia after cardiac arrest in humans was also described in the late 1950s1–3 but was subsequently abandoned because of uncertain benefit an...

Introduction Induction of moderate hypothermia (28°C to 32°C) before cardiac arrest has been used successfully since the 1950s to protect the brain against the global ischemia that occurs during some open-heart surgeries. Successful use of therapeutic hypothermia after cardiac arrest in humans was also described in the late 1950s1–3 but was subsequently abandoned because of uncertain benefit an...

What is the major problem being addressed by this study? Children with single ventricle congenital heart lesions account for 25-40% of all neonatal cardiac deaths. Between 35-50% of these kids will experience an unanticipated acute cardio-respiratory arrest event within the first months of life, and 15% will not survive. This study addresses the current inability to accurately detect the onset ...

We report the case of a 79-year-old woman who presented to our hospital for elective removal of an infratentorial meningioma and suffered a periprocedural cardiac arrest. Shortly after uncomplicated induction of anesthesia prior to the surgery, the patient became hypotensive and bradycardic, culminating ultimately in a cardiac arrest with pulseless electrical activity. Return of spontaneous cir...