Cloned murine helper T cells, restricted to the Iab antigens of the major histocompatibility locus and specific for horse erythrocytes as a foreign antigen, produce, in cooperation with antigen and histocompatible adherent cells, soluble factors that replace the helper T cells in their action on B cells. Three types of factors can be distinguished on the basis of molecular weight: proteins havi...

Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemi...

Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the focus being on the heavy chain complementarity-determining region (CDR)-H3 region. In this paper, we set out to investigate the physicochemi...

A copy DNA (cDNA) corresponding to sheep immunoglobulin E (IgE) heavy chain messenger RNA (mRNA) has been isolated and sequenced. A fragment of the sheep epsilon (E) chain was initially synthesized using the polymerase chain reaction (PCR) and single stranded cDNA prepared from the mRNA of parasite stimulated sheep lymph nodes. This fragment was then used to probe a cDNA library, again prepared...