An attempt was made to formulate Buccal patches of Isoxsuprine hydrochloride, a potent and long acting vasodilator and uterine suppressant , by using Hydroxyl propyl methyl cellulose(HPMC), Polyvinyl pyrolidone K-30 (PVP K-30) and Hydroxyl ethyl cellulose (HEC). Twelve batches of buccal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers ...

Identification of novel factors critical for epithelial to mesenchymal transition (EMT) and cancer initiating cell (CIC) formation may aid in the identification of novel therapeutics for the treatment of endometrial cancer. The present study demonstrated that L1 cell adhesion molecule (CAM) is critical for EMT and formation of CICs in endometrial cancer. Overexpression of L1CAM may promote EMT ...

The asynchronous transfer mode (ATM) is a promising technique for broadband switching that is capable of supporting high-bit-rate multimedia services. Progress in all-optical parallel processing shows that photonics may be used in the future in full-functionality ATM switching nodes. All-optical switching fabrics and buffers have already been demonstrated. Fewer studies have been dedicated to A...

Chemotherapy-induced nausea and vomiting (CINV) is a serious adverse effect of chemotherapy that limits patients' physical, mental, and functional capabilities and may cause a delay or cessation of treatment. Antiemetic therapy can reduce the incidence of CINV. Research, using data from visits by patients receiving moderately (MEC) or highly emetogenic chemotherapy (HEC), identified that antiem...

The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein microtubule-associated protein 1 light chain 3α (GFP-LC3) protein aggregates wer...

Towards the end of the 1980s, the issue of whether IS case research was rigorously conducted was first raised. Benbasat et al. (1987) and Lee (1989) formulated some key recommendations on how to conduct high quality case study research in our field. Since then, qualitative research, in general, and case research in particular, has evolved and grown considerably. For example, researchers from se...

OBJECTIVE We compared profiles of the numbers of circulating endothelial cells (CEC) and the apoptosis-inducing capacity of serum samples on human endothelial cells (hEC) in on-pump and off-pump coronary artery bypass grafting (CABG) patients. METHODS Blood samples from 30 patients undergoing CABG (randomly assigned to two groups: 15 patients off-pump and 15 on-pump (cardiopulmonary bypass, C...

Spyridon Orestis Palermos This paper focuses on the hypothesis of the extended cognition (HEC), and in particular, on two interrelated objections to it, namely the coupling-constitution fallacy and the cognitive bloat worry. Briefly, if there is no principled way in which we can decide whether a (cognitive) process depends on extra-neural (or extra-organismic) factors in a causal, or constituti...

The bioavailability of the major fraction of a 14C-labeled Escherichia coli extract (OM-89) of high molecular mass > 30 kD (HEC) was investigated in rats after a single oral administration of a dose of 100 mg/kg b.w. The determination of radioactivity in blood and plasma showed that HEC was absorbed by the digestive tract, either in its original form or partly degraded. In plasma, the radioacti...

Molecular mobility has long been established to relate to textural properties and stability of polymer films and is therefore an important property to characterise to better understand pharmaceutical film formulations. The molecular mobility of solvent cast hydroxyethyl cellulose (HEC) films has been investigated by means of thermally stimulated current (TSC) below the temperature at which the ...