The present study aimed to establish hyperinsulinemic euglycemic step clamping with tracer glucose infusion and labeled glucose infusate (step hot-GINF HEC) for assessment of acute insulin resistance in anesthetized pigs and to arrange for combination with invasive investigative methods. Tracer enrichment was measured during D-[6,6-(2)H(2)]glucose infusion before and after surgical instrumentat...

BACKGROUND The objective was to evaluate the cost-effectiveness of NEPA, an oral fixed combination netupitant (NETU, 300 mg) and palonosetron (PA, 0.5 mg) compared with aprepitant and palonosetron (APPA) or palonosetron (PA) alone, to prevent chemotherapy-induced nausea and vomiting (CINV) in patients undergoing treatment with highly or moderately emetogenic chemotherapy (HEC or MEC) in the UK....

Quantum states with geometric duals are known to satisfy a stricter set of entropy inequalities than those obeyed by general quantum systems. The allowed entropies derived using the Ryu-Takayanagi (RT) formula defines Holographic Entropy Cone (HEC). These no longer satisfied once corrections included employing Extremal Surface (QES) prescription. Nevertheless, structure QES allows for controlle...

The present study was undertaken to determine whether endometrial cancer cell line HEC-1-A differ from nontransformed cells, in that the cAMP and protein kinase C pathways may enhance IGF-I effects in mitogenesis by acting at the G1 phase of the cell cycle instead of G0. Immunofluorescence staining of HEC-1-A cells using the proliferating cell nuclear antigen (PCNA) monoclonal antibody and flow...

The swift fox (Vulpes velox) is a small canid currently listed as endangered in the state of Nebraska. Current and future construction of the Heartland Expressway Corridor (HEC) through the Nebraska panhandle may be a cause for concern for resident swift fox populations. Current swift fox presence along the roadway will be documented before construction continues. We surveyed for swift foxes wi...

The effects of specific and non-specific regulation of matriptase on endometrial cancer cells in vitro were investigated. Messenger ribonucleic acid (mRNA) and protein expression of matriptase and hepatocyte growth factor activator inhibitor-1 (HAI-1) in RL-952, HEC-1A, and HEC-1B endometrial cancer cells were detected by real-time quantitative PCR (RT-qPCR) and western blot. The cells were inf...

Entry of vesicular stomatitis virus (VSV), the prototype member of the rhabdovirus family, occurs by receptor-mediated endocytosis. Subsequently, during traversal through the endosomal compartments, the VSV G protein acquires a low-pH-induced fusion-competent form, allowing for fusion of the viral membrane with endosomal and lysosomal membranes. This fusion event releases genomic RNA into the c...

The purpose of the present study was to investigate the effect of ethanol extracts from red pepper seeds on the antioxidative defense system and oxidative stress in rats fed a high fat . high cholesterol diet. Rats were divided into four experimental groups which were composed of high fat . high cholesterol diet group (HF), high fat . high cholesterol diet with 0.1% ethanol extracts from red pe...

Computer applications to storm runoff prediction have revolutionized the watershed modeling techniques. In general, a watershed is modeled as a system with inputs and outputs (Chow 1964). A system can be lumped or distributed, depending upon the spatial and temporal characteristics of the design variables used in the model. A lumped parameter ignores the variability in space. On the other hand,...

According to the hypothesis of extended cognition (HEC, hereafter), human cognitive processing extends beyond the boundary of the human organism. 2 philosophy of cognitive science; HEC is supposed to reveal something important about human beings' core cognitive faculties and, in doing so, reshape the study of human cognition. Although many authors have reacted to HEC with reasoned skepticism, 2...