allogeneic hematopoietic stem cell transplantation is used in the treatment of patients suffering from hematologic and non-hematologic disorders, but the application is limited by the identification of a suitable donor. umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell (hsc) transplantation. despite all advantages, the limited cell dose is one of the  major obstacle...

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...

background the aim of this study was the ex vivo expansion of umbilical cord blood hematopoietic stem cells on biocompatible nanofiber scaffolds. materials and methods cd133+ hematopoietic stem cells were separated from umbilical cord blood using midimacs (positive selection) system by means of monocolonal antibody cd133 (microbeads) subsequently, flowcytometry method was done to assess the pur...

Background The aim of this study was the ex vivo expansion of Umbilical Cord Blood hematopoietic stem cells on biocompatible nanofiber scaffolds. Materials and Methods CD133+ hematopoietic stem cells were separated from umbilical cord blood using MidiMacs (positive selection) system by means of monocolonal antibody CD133 (microbeads) subsequently, flowcytometry method was done to asses...

allogeneic hematopoietic stem cell transplantation (hsct) is a curative treatment option for hematological disorders. cyclosporine (csa) is one of the major immunosuppressive agents for the prophylaxis against graft versus host disease (gvhd). in this retrospective study, we evaluated the effects of csa serum levels on the incidence of acute gvhd and transplant outcomes. 103 adult patients rece...

background: it is suggested that ha-1 mismatching among hematopoietic stem cell transplanted recipients-donors is associated with acute graft-versus-host disease (agvhd). so the aim of this study was to evaluate ha-1 frequency and examine the correlation between ha-1 disparity and gvhd patients who received transplantation from a hla-identical sibling. samples and methods: the dna was extracted...

background: the aim of the present clinical trial was to investigate the efficacy of autologous bone marrow mesenchymal stem cells (bm-mscs) in glycemic control of diabetic patients without using any immunosuppressive drugs over a nine-month period. method: twenty-three patients with t1dm, at 5 to 30 years of age and in both sexes, participated in this study. this trial consisted of two phases;...

background: vancomycin is used abundantly in patients undergoing hsct, especially during neutropenic fever. despite its widespread use little is known about vancomycin pharmacokinetics in hsct patients. we conducted this study to investigate vancomycin pharmacokinetic parameters in our hsct patients and to evaluate current dosing regimen based on trough vancomycin concentrations measurement. me...