Heme arginate infusions blunt the symptoms of patients with acute intermittent porphyria without evidence of the vascular or thrombotic side effects reported for hematin. To provide a rationale for heme arginate's safety, the present study examined the effects of various ferriporphyrins to sensitize human endothelial cells to free radical injury and to induce heme oxygenase and ferritin express...

Chi-Chih Hung, Xiaoli Liu, Min-Young Kwon, Young-Ho Kang, Su Wol Chung, and Mark A. Perrella Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Newborn Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; and Departmen...

........................................................................................................................................... ii Co-Authorship ................................................................................................................................ iii Acknowledgements .............................................................................................