Tuberculosis (TB), a common health problem in developing countries, is a specific multi-systemic infection that can lead protean manifestations in any organ system. Anemia and leukocytosis are the most frequent hematological findings at presentation and during the long clinical course of the disease. Coombs’-positive hemolytic anemia and immune thrombocytopenic purpura (ITP) are exceedingly rar...

Visceral leishmaniasis (VL) is an intracellular parasitic infection that infects and multiplies in the macrophages of the liver, spleen and bone marrow. It is characterized by intermittent fever, hepatosplenomegaly, pancytopenia and hypergammaglobulinemia. Anemia of multifactorial etiology is a usual manifestation of VL; however, Coombs positive hemolytic anemia has been infrequently reported i...

Compound heterozygosity for βS/βD results in a severe hemolytic anemia and a clinical syndrome similar to that of sickle cell disease. Here, we report a case of HbSD Punjab disease. A 10 year old female child residing at Nagpur, Maharashtra presented with severe hemolytic anemia, hepatosplenomegaly and occasional pains in bones and abdomen. Initially, she was thought to be a case of sickle cell...

Congenital hemolytic anemia associated fancy. The peripheral blood smear is charwith pyrimidine 5’-nucleotidase deficiency acterized by striking red cell basophilic is reported in two siblings. Both have had stippling. As this feature has been found moderate chronic hemolytic anemia, splein all previously reported cases, it should nomegaly, and jaundice since early inbe the clue to the diagnosis.

This case highlights the importance of considering infectious etiology in the management of hemolytic anemia. Hemolytic anemia associated with infectious endocarditis is rare. Actinomyces endocarditis is a rare occurrence and is very challenging to diagnose given the challenges to culture the organism.

Congenital hemolytic anemia associated with pyrimidine 5'-nucleotidase deficiency is reported in two siblings. Both have had moderate chronic hemolytic anemia, splenomegaly, and jaundice since early infancy. The peripheral blood smear is characterized by striking red cell basophilic stippling. As this feature has been found in all previously reported cases, it should be the clue to the diagnosis.

Rasburicase for the treatment of tumor lysis syndrome has been associated with hemolytic anemia and methemoglobinemia, usually in patients with G6PD deficiency. Risks and benefits should be considered prior to use of rasburicase in at-risk patients. Methylene blue will worsen the hemolytic anemia in G6PD deficiency and should be avoided.

A 48 year old lady presented with jaundice and exertional breathlesness. Her laboratory reports showed anaemia, reticulocytosis, leucocytosis, elevated Lactate Dehydrogenase (LDH), alkaline phosphatase levels, hyperbillirubinemia and positive direct Coomb's test. After ruling out all the other causes of autoimmunity and hemolytic anemia, she was diagnosed as leukemoid reaction due to autoimmune...

A 49-year-old female presented with autoimmune hemolytic anemia and positive warm antibodies. She was diagnosed with chronic pulmonary sarcoidosis. The patient was given prednisolone after which she had complete remission of autoimmune hemolytic anemia and stabilization of her pulmonary status. A review will follow on association of sarcoidosis with autoimmune disease and its possible role in t...

Infantile pyknocytosis is a rare cause of neonatal jaundice and hemolytic anemia. We report on two cases in twin girls that were diagnosed on peripheral blood smear reading. Pyknocytosis should be considered in cases of early unexplained severe hemolytic anemia, and systematic peripheral smear review performed. Its management consists of phototherapy and RBC transfusion.