patients with end stage renal disease need a good vascular access for hemodialysis. arteriovenous fistula is the method of choice for vascular access in these patients. however, failure of arteriovenous fistula due to thrombosis is a major problem. the aim of this study was to evaluate the effect of the heparin on the patency of the arteriovenous fistula. this prospective interventional case co...

conclusions it seems that there is no difference in the use of heparinized and normal saline solutions to prevent catheter occlusion of arterial and central venous pressure. patients and methods in the current randomized controlled trial, 100 patients, with an age range of 18 - 65 years of valve and coronary artery surgery were studied in rajaie heart center, tehran, iran. patients were randomi...

objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

objective: several studies have shown the improving effect of heparin on the outcomes of art. moreover, it has been reported that adding heparin in non-thrombophilia patients with rif is useful.the aim of this study was to evaluate the beneficial effects of heparin on art outcomes in women with history of recurrent implantation failure (rif) and without history of congenital or acquired thrombo...

Objective: Heparin and enoxaparin possess anti-inflammatory properties. We compared the effects of these drugs on inflammatory biomarkers in patients with ST-segment Elevated Myocardial Infarction (STEMI). Method: Thirty four patients with STEMI randomly separated in two groups and received standard doses of heparin and enoxaparin. The serum concentration of Serum Amyloid A (SAA), C-Reactive Pr...

background: low molecular weight heparin (lmwh) is used for the treatment and prevention of coagulative disorders. few patients receiving therapeutic doses of lmwh develop major hemorrhage. currently there are few reports in the literature on acute overdose on adults.  in this study, clinical profile, treatment and outcome of 21 patients who acutely overdosed enoxaparin are described. methods: ...

Background: Prevention of catheter-related infection is of prime importance,. However, because of the risks caused by the leakage of circulating antibiotics and development of resistance to antibiotics, they are replaced by lock solutions. The aim of this study was to evaluate the efficacy and cost- effectiveness of taurolidine-citrate as a hemodialysis catheter lock solution compared to other ...

The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates iron availability in our body. Hepcidin expression influenced by hepatic heparan sulfate (HS) and heparin administration, suggesting BMP6 interaction with heparin/HS. BMP2/4 subfamily has been deeply characterized to have N-terminal heparin/HS binding domain (HBD), whose basic residues c...

Standard-dose heparin protocol (SDP) is the standard anticoagulant of unfractionated (UFH) for maintenance hemodialysis. To alleviate side effect heparin, low-dose (LDP) has been proposed, however, studies were scarce and inconclusive.

materials and methods in a double blind randomized trial study, 100 patients undergoing elective cardiac surgery were randomized to using heparinized (n = 50) or non-heparinized (normal) saline flush (n = 50) to maintain patency of arterial catheter after operation. indwelling arterial catheters were checked daily for acceptable arterial waveform for three days as primary outcome measures. resu...