Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within hepatocytes. APAP hepatotoxicity remains a global issue; in the United States, in particular, it accounts for more than 50% of overdose-related acute...

BACKGROUND AND AIM The data available on subacute hepatic failure due to hepatitis E virus is scarce. The aim of this study is to analyze the clinical spectrum and outcome of this condition. METHODS This is a retrospective hospital-based study of patients with acute hepatitis E and subacute hepatic failure from January 2001 to June 2006. RESULTS We encountered 12 patients with this conditio...

advancements in medical science have led to the development of complex surgeries that improve survival in patients with liver disease. assessments of the indications and contraindications for surgery and risk factors are the most important steps prior to any surgery in this population. particular attention is essential to assess for the presence of pre-surgical ascites, hepatic encephalopathy a...

abstract acase of 48-year-old male, hepatitis b cirrhosis , hepatic hydatid cyst, jaundice, fever, chills suffered from severe abdominal pain in the right upper quadrant. he was suffered from acute cholangitis and spontaneous bacterial peritonitis, and received intravenous antibiotics but his condition rapidly deteriorated to sepsis and severe hepatic failure. the presence of dilated common bil...