Abstract: Background: Hepato-Renal impairment refers to renal dysfunction in a liver compromised state concerning lead metal exposure. Natural chelators (marine source) have potent chelating properties claiming ameliorate hepato-renal heavy toxicity Material and Methods: A total of 42 male albino Wistar rats weighing between 200 250 g were categorised into seven groups (n=6). Except for the fir...

A syndrome with distinctive clinical features affecting brain, liver and kidneys was described by Bowen et al in 1964 1 and Smith et al. in 1965 2 . In 1973 Goldfisher et al 3 has reported that peroxisomes were absent in the liver and kidneys of affected children. More recently lack of dihydroxyacetone phosphate acyletransferase (DHAP-AT) a peroxisomal enzyme with a major role in glycerol ether...

Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycos...