discrimination of regenerative cirrhotic nodules of the liver (cn) from hepatocellular carcinoma (hcc) is sometimes difficult. we examined the utility of agnor staining in this context. fifteen cases of hcc and 25 cases of cn were stained by agnor method and the mean agnor number for one hundred nuclei in each case was determined. there was a significant difference between the mean agnor counts...

objectives and background: mutation directed inactivation of the tumor suppressor gene p53 have been found incountries with high frequency for hepatocellular carcinomas (hccs). our goal in the present study was screening of the p53 gene in tumor tissues from hcc affected individuals in southwest iran for putative mutations in exons 7 and 8 that are known as hot spot regions. materials & met...

Recently developing countries showing growing trend in hepatocellular carcinoma cases. Hepatocellular metastasis to oral cavity is uncommon finding. Most common site for mets lung, breast, kidney. Data on HCC limited. We present here one such rare case of cavity. Awareness about the entity helps early diagnosis and management that leads better prognosis good quality life patient.

BACKGROUND The clinical significance of miR-141-3p in hepatocellular carcinoma has not been verified. Therefore, we conducted this study to examine miR-141-3p expression and its clinical significance in hepatocellular carcinoma and to investigate the functions of its potential targets. METHODS The Cancer Genome Atlas database and the Gene Expression Omnibus database were used to explore the a...

PURPOSE To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage. EXPERIMENTAL DESIGN MDK expression in tumors was assessed by immunohistochemistry from 105 patients with hepatocellular carcinomas or liver cirrhosis. Serum MDK levels were detected by ELISA in 933 parti...

Purpose: To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage. Experimental Design: MDK expression in tumors was assessed by immunohistochemistry from 105 patients with hepatocellular carcinomas or liver cirrhosis. SerumMDK levels were detected by ELISA in 933 partic...

Hepatocellular adenoma is a very rare disease in Japan, and institutions encounter only a limited number of cases. This is one of the reasons for the current skepticism in Japan over whether hepatocellular adenoma can truly undergo malignant transformation to hepatocellular carcinoma. However, hepatocellular adenoma is highly prevalent in Western countries, particularly in Europe, and textbooks...

background: during the resent years there has been interest in using bone marrow stem cells to treat liver cirrhosis. however, there is a potential concern for malignant transformation after stem cell therapy. the aim of this study was to evaluate the development of hepatocellular carcinoma (hcc) after autologous bone marrow stem cell transplantation for liver cirrhosis. methods: all the patien...

Although multiple environmental cues regulate the transition to flowering in Arabidopsis thaliana, previous studies have suggested that wild A. thaliana accessions fall primarily into two classes, distinguished by their requirement for vernalization (extended winter-like temperatures), which enables rapid flowering under long days. Much of the difference in vernalization response is apparently ...

BACKGROUND Liver transplantation is the usual treatment for hepatocellular carcinoma. AIM To analyze the MELD score, waiting time and three month and one year survival for liver transplantation in cirrhotic patients affected by hepatocellular carcinoma or not. METHODS This was a retrospective, observational and analytical study of 93 patients submitted to liver transplantation. RESULTS Th...