نتایج جستجو برای: hepatocyte

تعداد نتایج: 29886  

2013
Mahdokht Hossein Aghdaie Bita Geramizadeh Negar Azarpira Elahe Esfandiari Masoume Darai Marjan Rahsaz Saman Nikeghbalian Seyed Ali Malekhosseini

BACKGROUND Hepatocyte transplantation is being used in patients with liver-based metabolic disorders and acute liver failure. Hepatocytes can be isolated from unused/rejected livers under sterile conditions. OBJECTIVES The quality of the hepatocytes is very important and the main and initial step in hepatocyte transplantation is hepatocyte isolation. In this study we tried to set up the metho...

2012
L. Wang J. Wang X. Zhou J. Li Y. Shi Z. Han X. Wang S. Li Z. Yang R. Wang D. Fan Y. Han

The polarized molecules predominately distributing at hepatocyte canalicular surface play a vital role in disclosing the process of bile formation and etiopathogenisis of cholestatic live diseases. Therefore, it is important to find novel polarized molecules on hepatocyte canalicular membrane. In the present study, canalicular membrane vesicles (CMVs) isolated from rat hepatocyte by density gra...

Journal: : 2021

The article presents data on pathomorphological changes of the digestive organs in associative course heterakidosis and histomoniasis turkeys. Changes liver were observed 57.1% cases: protein fatty dystrophy, hepatocyte necrosis. cеcal lesions 100% cases, mainly fibrinous inflammation. In other parts intestinal tract – acute catarrhal

Journal: :The Journal of experimental biology 2004
Paul L Else M D Brand N Turner A J Hulbert

Hepatocytes were isolated from eight species of birds ranging from 13 g zebra finches to 35 kg emus. This represents a 2800-fold range of body mass (Mb). Liver mass (g) was allometrically related to species body mass by the equation: liver mass=19.6 x Mb(0.91). There was a significant allometric decline in hepatocyte respiration rate (HRR; nmol O2 mg(-1) dry mass min(-1)) with species body mass...

Journal: :The Biochemical journal 1998
J Chen E J Ishac P Dent G Kunos B Gao

To understand the mechanisms by which ethanol inhibits hepatocyte proliferation, we studied the effects of ethanol on p42/44 mitogen-activated protein kinase (MAPK), p38 mitogen-activated protein kinase (p38 MAPK) and c-Jun N-terminal kinase (JNK) in normal and regenerating rat liver. Treatment of rat hepatocytes with 100 mM ethanol in vitro for 16 h prolonged the activation of p42/44 MAPK and ...

Journal: :American journal of physiology. Cell physiology 2003
Hongtao Guo Junping Wei Yusuke Inoue Frank J Gonzalez Paul C Kuo

Nitric oxide (NO), endogenously synthesized by inducible NO synthase (iNOS), serves antioxidant and antiapoptotic functions in settings characterized by oxidative stress and proinflammatory cytokines such as sepsis and shock. However, the redox-sensitive mechanisms regulating hepatocyte expression of iNOS are largely unknown. In interleukin-1beta (IL-1beta)-stimulated hepatocytes exposed to sup...

Journal: :American journal of clinical pathology 2009
Mylinh T Mac Fai Chung Fan Lin Pei Hui Bonnie L Balzer Hanlin L Wang

Hepatocyte antigen is recognized by antibody Hep Par 1, a widely used diagnostic immunomarker for hepatocellular carcinoma and tumors with hepatoid differentiation. Hepatocyte antigen expression has also been detected in nonneoplastic small intestinal epithelium, but expression in small intestinal adenocarcinoma has not been well investigated. We immunohistochemically examined 39 nonampullary s...

Journal: :Biochemical Society transactions 2000
R Coleman M G Roma

Hepatocyte couplets, by retaining functional and morphological polarity similar to that of hepatocytes in situ, are a valuable in vitro model to study mechanisms of bile secretion, cholestasis and hepatocellular injury. They have been useful in studies of the hormonal control of bile formation and are suitable for morphological studies. The availability of periportal- and perivenous-enriched co...

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