نتایج جستجو برای: hepatocyte

تعداد نتایج: 29886  

2005
Gregory H. Underhill Jennifer Felix Jared W. Allen Valerie Liu Tsang Salman R. Khetani Sangeeta N. Bhatia

1. Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419 1.1. Liver Disease and Cell-Based Therapies . . . . . . . . . . . . . . . . . . . . . . . . 419 1.2. Cell Sources for Liver Cell-Based Therapies . . . . . . . . . . . . . . . . . . . . 419 1.3. Approaches for the In Vitro Stabilization of Primary Hepatocytes . 420 1.4....

2006
Tae Hyeon Kim Eun Young Cho Hyo Jeong Oh Chang Soo Choi Ji Woong Kim Heung Bae Moon Haak Cheul Kim

Subcellular localizaton of HBcAg have been found to be related to the activity of liver disease and HBV replication. The aim of this study was to determine whether the degree of expression of HBcAg in the hepatocyte nucleus and cytoplasm reflects the level of viral replication and histological activity in chronic HBV infection. A total of 102 patients with biopsy proven chronic hepatitis B were...

2014

The prediction of human drug metabolites using in vitro experiments containing human-derived reagents is an important approach in modern drug research; however, this can be challenging for drugs that are slowly metabolized. In this report, we describe the use of a recently developed human hepatocyte relay method for the purpose of predicting human drug metabolite profiles. Five compounds for wh...

2014

Due to the importance of in vitro cytochrome P450 (P450) induction assay to assess the possible drug-drug interaction events, the recent US Food and Drug Administration draft guidance and European Medicines Agency guideline recommend to assess P450 induction using fresh or cryopreserved hepatocytes at mRNA level and/or enzyme activity level. Although cryopreserved hepatocytes are commercially a...

2017
Maëlle Lorvellec Federico Scottoni Claire Crowley Rebeca Fiadeiro Panagiotis Maghsoudlou Alessandro Filippo Pellegata Francesca Mazzacuva Asllan Gjinovci Anne-Marie Lyne Justine Zulini Daniel Little Olukunbi Mosaku Deirdre Kelly Paolo De Coppi Paul Gissen

Liver transplantation is the definitive treatment of liver failure but donor organ shortage limits its availability. Stem cells are highly expandable and have the potential to differentiate into any specialist cell. Use of patient-derived induced Pluripotent Stem Cells (hiPSCs) has the additional advantage for organ regeneration therapies by removing the need for immunosuppression. We compared ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Jesse Summers Allison R Jilbert Wengang Yang Carol E Aldrich Jeffry Saputelli Samuel Litwin Eugene Toll William S Mason

We estimated the amount of hepatocyte turnover in the livers of three woodchucks undergoing clearance of a transient woodchuck hepatitis infection by determining the fate of integrated viral DNA as a genetic marker of the infected cell population. Integrated viral DNA was found to persist in liver tissue from recovered animals at essentially undiminished levels of 1 viral genome per 1,000-3,000...

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