Neurofibrillary degeneration is well correlated to the clinical signs of Alzheimer disease. However, the amyloid cascade is so well established in the scientific and medical community that the role of neurofibrillary degeneration in Alzheimer's disease etiopathogenesis is often underestimated. However, neuronal vulnerability is clearly a key factor for facilitating the amyloid pathology which a...

Symptomatic disc degeneration is a complex pathological condition that involves a cascade of events and is not totally understood. In this context, animal models gain an important role, allowing for better understanding of the degenerative process and therapeutic interventions. There are several models with different methods of evaluation of experimental disc degeneration (EDD), including imagi...

Copper was measured by atomic absorption spectrometry in sweat samples obtained during sauna bathing (15 min at 93 °) from seven patients (2 5 5) with Wilson’s disease (hepatolenticular degeneration). In one patient who was not being treated with penicillamine, the estimated excretion of copper in total body sweat during the sauna bath was 18 /¿g. In six patients who were receiving oral penicil...

Computed tomography (CT) was performed on 25 patients with Wilson disease (hepatolenticular degeneration). The diagnosis was confirmed biochemically. CT was normal in seven patients, five of whom presented clinically with the hepatic form of the disease. In 10 patients, CT abnormalities were graded as mild: there were atrophic changes around the basal ganglia and in the cortex and cerebellum. I...

The therapeutic history of sodium diethyldithiocarbamate (dithiocarb) is briefly reviewed. Dithiocarb was discovered serendipitously in our laboratory 35 years ago for the specific treatment of nickel carbonyl poisoning. Since that time, the therapeutic efficacy of dithiocarb has been reported for many disorders, including: nickel, cadmium, thallium, copper, and mercury poisonings, experimental...

this review covers some of the developments during this period. Just over twenty years ago J. R. M. Innes came to the National Hospital for Nervous Diseases and showed us some intriguing pictures of lambs with sway-back and suggested that here was a demyelinating disease which could be prevented by giving the ewes copper. Then, during the war, four workers studying sway-back developed themselve...

The present note provides an overview of the historical development of neurology and its current status in the People's Republic of China, against the backdrop of the current massive transformation of Chinese society. We trace the origins of neurology in China to missionary medicine during the Republican period (1911-1949), and describe how the discipline grows with difficulty throughout the su...