To investigate the hepatoprotective potential of ethanolinc grape seed extract on acetaminophen (APAP) induced liver toxicity in wistar rats. Silymarin was used as reference hepatoprotective agent. Liver injury was induced by APAP (2 gm/kg body weight, bw) on the 1st day of experiment. Vitis vinifera (V. vinifera)L seed extract (200 and 400 mg/kg bw) and silymarin (100 mg/ kg bw) was administer...

treatment of diseases with natural remedies is gaining popularity because of its fewer side effects.   a systemic and scientific investigation of aqueous extract of euphorbia tirucalli for its antioxidant and hepatoprotective potential against carbon-tetrachloride-induced hepatic damage in rats was carried out . antioxidant property was assessed by using reducing property, superoxide anion scav...

The objective of the study was to investigate the methanol extract of Pavonia zeylanica (MEPZ) against acetaminophen induced hepatotoxicity and antioxidant activity in Wistar albino rats.The methanol extract of pavonia zeylanica (200, and 400 mg/kg body weight) was administered orally to two groups of rats (six animals per group) in order to evaluate the protective effect of the extract in rats...

The present study was designed to investigate the synergistic hepatoprotective effect of Silymarin in combination with standardised extracts of Picrorrhiza kurroa, Phyllanthus amarus, Tephrosia purpurea, Asparagus racemosus plants against experimental hepatotoxicity induced by administration of Paracetamol (3g/kg; p.o) and Carbontetrachloride (1ml/kg; s.c) in wistar rats. Paracetamol and CCl4 i...

The objective of the present study appraised the hepatoprotective activity of methanolic extract of Melia azedarach. L leaves on Wistar rats. The Methanolic extracts of Melia azedarach. L (200mg & 500mg/kg,b.w,p.o) was administered respectively to the animals which were treated with carbon tetrachloride. Its effects on biochemical parameters were compared with standard drug silymarin (100mg/kg,...

The protective effects of oleanolic acid-type saponins and their derivatives on in vitro immunological liver injury of primary cultured rat hepatocytes were studied. A known antihepatotoxic saponin (chikusetsusaponin IVa, 1) showed hepatoprotective activity in this model. Although a rhamnosyl derivative (2) of 1 similarly showed hepatoprotective activity, its prosapogenin (5) did not show any h...

Swertia mussotii Franch. (SM) (Gentianaceae) was a traditional Tibetan folk herb for hepatitis in the Qinghai-Tibet plateau areas. For understanding the hepatoprotection and toxicity characteristics of Swertia mussotii Franch., the whole plant of Swertia mussotii was extracted by water (SME-b) and 75% ethanol (SME-a); then, SME-a was dissolved with water, the supernatant was SME-c, and the sedi...

Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dried mung bean and amino-acid- and GABA-enriched germinated and fermented mung ...

Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Cuscuta campestris Yunck. whole plant (CCEtOH). The hepatoprotective effect of CCEtOH (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl₄)-induced chronic liver injury. Serum alanine aminotransferase, aspartate ...