HALOGENATED anesthetic agents have been associated with perioperative liver dysfunction and injury. Most cases of hepatotoxicity reported involve halothane exposure. Halothane produces two types of hepatotoxicity. A mild, transient syndrome with modest increases in transaminase enzymes occurs in 20% of patients given halothane. A more severe and fulminant hepatitis with marked liver dysfunction...

Triptolide, the major active component of Tripterygium wilfordii Hook f. (TWHF), has a wide range of pharmacological activities. However, the toxicities of triptolide, particularly the hepatotoxicity, limit its clinical application. The hepatotoxicity of triptolide has not been well characterized yet. The aim of this study was to investigate the role of NF-E2-related factor 2 (Nrf2) in triptoli...

Hepatotoxicity secondary to carbamazepine is a serious condition which can be fatal. However, other concomitant medications or environmental factors may be the offending agents. In this case report, hepatotoxicity secondary to organic solvents and paints is described.

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with high dose paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent risk factor for hepatotoxicity, could A. cordifolia play key role to limit their hepatotoxicity? objective this study assess the histological changes rat livers and evo...

hydroxypyridinone iron chelators are currently the main candidates for development of orally active iron chelating alternatives to desferrioxamine (dfo). in the present study, the relative efficacy and liver toxicity of a bidentate chelator, 2-methyl-3-hydroxypyridin-4-one (mhpo), was studied in iron overloaded rats and compared with those of dfo. for iron overloading, rats received i.p. inject...

It has been estimated that 10% of acute liver failure is due to "idiosyncratic hepatotoxicity". The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were included in this study: two overt hepatotoxicants (acetaminophen and carbon tetrachloride), two idio...

Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It a heavy metal with number of side effects, including hepatotoxicity. Resveratrol (Rs) considered an important polyphenol, which secondary plant metabolite has the ability to scavenge free radicals. The study was designed evaluate effects resveratrol on Cd, induced hepatotoxicity, by assessment histopathological bio...

Abstract Background Acetaminophen overdose is the leading cause of acute liver injury (ALI) and failure (ALF) in developed world. We aimed at studying therapeutic potential bone marrow mesenchymal stem cells (MSCs) accelerating healing acetaminophen-induced hepatotoxicity. Results This prospective study included 50 male albino rats divided into 2 groups: hepatotoxic group non-hepatotoxic group....

BACKGROUND The liver is vulnerable to injury from the first line anti-tuberculosis drugs. This may result in mortality, long term morbidity and reduced compliance to therapy. Nigeria recently introduced fixed drug combinations in the treatment of children amid concerns of hepatotoxicity. A 6-year-old boy was treated in our unit had fulminant hepatic failure two weeks after completing his anti-t...

Acetaminophen (APAP) hepatotoxicity is the main cause of acute liver failure in humans. Although mitochondrial oxidant stress and induction of the mitochondrial permeability transition (MPT) have been implicated in APAP-induced hepatotoxicity, the link between these events is unclear. To investigate this, this study evaluated APAP hepatotoxicity in mice deficient of cyclophilin D, a protein com...