introduction: glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. although changes in tnfα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. we investigated the effect of microinfusion of tnfα into the lc in a rat model of neuropathic pain. methods: male wistar rats wer...

BACKGROUND Several studies have described pain prevalence, risk factors, pain and medical variables in spinal cord injury (SCI) populations. In this study on traumatic SCI in Turkey, we surveyed the neuropathic pain experiences during in-patient rehabilitation and defined the relationships between neuropathic pain and demographic and SCI characteristics of patients. OBJECTIVES To survey the n...

Impaired Glial Glutamate Uptake Induces Extrasynaptic Glutamate Spillover in the Spinal 1 Sensory Synapses of Neuropathic Rats 2 3 Abbreviated title: role of glial glutamate transporters in neuropathic pain 4 5 Hui Nie and Han-Rong Weng* 6 7 Department of Pain Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, 8 Texas 77030 9 10 *Correspondence should be addressed to Han-R...

please cite this article as : moini zanjani t, saghaei e, ameli h, sabetkasaei m. anti-allodynic effect of nefopam and morphine in a rat model of neuropathic pain. novel biomed 2013;1:16-22. background: neuropathic pain is a chronic pain due to a disorder in the peripheral or central nervous system with different pathophysiological mechanisms. current treatments are not effective. here we compa...

Peripheral neuropathy is caused either by diseases or trauma to the nerve or the side effects of systemic illness or due to the neurotoxicity and due to some drugs as a side effect. Owing to peripheral neuropathy, patients suffer from neuropathic pain. In this review author strive to gathered succinct literature on diversified therapeutic agents used for the treatment of neuropathic pain, with ...

Cannabis has been widely used as a medicinal agent in Eastern medicine with earliest evidence in ancient Chinese practice dating back to 2700 BC. Over time, the use of medical cannabis has been increasingly adopted by Western medicine and is thus a rapidly emerging field that all pain physicians need to be aware of. Several randomized controlled trials have shown a significant and dose-dependen...

Dr McCarberg is Assistant Clinical Professor (voluntary), University of California School of Medicine, Boarded in Family Medicine, Geriatrics, and Pain Medicine, Family Medicine Kaiser Permanente, San Diego, California. Conflict of Interest: The author reports serving on the speaker’s bureau for Eli Lilly, Endo, Forest, Janssen, Ligand, Organon, Ortho-McNeil, Pfizer Inc, PriCara, and Purdue. Of...

Neuropathic pain, caused by a lesion or disease affecting the somatosensory nervous system, has a substantial effect on quality of patient life. Given that the synthetic drugs can produce serious side effects they are not suitable for long-term use, therefore it is assumed that herbal medicine can be effective as an alternative to Analgesic agent. The aim of this study was evaluation the analge...

Neuropathic pain is intractable pain caused by damage to the nervous system. Recent approval and expansion of the indications of a series of drugs are expected to improve the treatment strategies for neuropathic pain. Here, we present an outline of pain transmission pathways and relevant pharmacological effects, along with points to consider in the use of neuropathic pain medications according ...