Herpes simplex virus type 1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes simplex virus type 1 and functions together with he...

brown alga, turbinaria conoides was successively extracted with n-hexane, cyclohexane, methanol and ethanol:water (1:1). the extracts were evaluated for antibacterial and antifungal activities by disc diffusion method. minimal inhibitory concentration was determined for active extracts by broth dilution method. the antiviral activity and cytotoxicity of the extracts were tested in human embryon...

background and aims: sexually transmitted infections (stis) are of major concern to clinicians and researchers in the field of reproductive medicine. many sti pathogens cause incurable and often fatal diseases, and have been transmitted through insemination procedures. the role of herpes simplex virus in male infertility has been investigated using the sensitive methods. the aim of this study w...

herpes simplex virus type 1 establishes a latent infection in the peripheral nervous system following primary infection. during latent infection, virus genome exhibit limited transcription, with the hsv lats consistently detected in latency infected ganaglia. following ocular infection viral latency develops in the trigeminal ganglia. in this study pcr has been used for detection of hsv-1 nucli...

purpose: to evaluate the effectiveness of corneal collagen cross-linking with uv-a and riboflavin (cxl) for treatment of refractory herpes simplex virus necrotizing keratitis. case reports: two patients with a diagnosis of hsv necrotizing stromal keratitis referred to khalili hospital eye emergency room and who were resistant to conventional treatment underwent cxl. response to treatment was ev...

purpose : the evaluation of the presence of herpes simplex virus (hsv) in corneal scars by real-time polymerase chain reaction (pcr) and comparison of the results with histopathologic findings and clinical diagnoses methods : eighty-seven corneal scar samples obtained after penetrating keratoplasty (pk), were selected after reviewing the records from 2006 to 2010. nucleic acid was extracted fro...

background herpes simplex virus infections are very common worldwide. the virus can cause infection in various body parts, especially eyes and the nervous system. therefore, an early diagnosis and highly sensitive method is very helpful. objectives the present study sought to investigate the efficiency of real-time taqman probe pcr in the diagnosis of hsv infection in suspected patients. patien...

The sensitization of herpes simplex virus by immunoglobulin G (IgG) antibodies was studied. Although herpes simplex virus sensitized by IgG could not be neutralized by IgA antibodies known to neutralize a similar number of unsensitized viruses, this protection could be overcome by larger amounts of IgA antibodies. This suggests that the effective neutralization of herpes simplex virus in ocular...

An avidin-biotin complex system was compared with three commercially available immunofluorescence kits for serotyping herpes simplex virus isolates from clinical specimens. Sensitivity values showed that the Electro-Nucleonics and Immulok reagents were useful in detecting the presence of virus, whereas the predictive values showed that the Syva and Immulok reagents possessed adequate discrimina...

Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates ...